Friday, June 07, 2019

What Ails Indian Education


No university can become a research university unless it possesses the following qualities: dedicated, brilliant students; internationally acclaimed faculty; international-level financial support; and full academic freedom


Much excitement was created when the latest (2005/06) budget granted one billion rupees (US$22 million) to the 11Sc. The IITs, too, have now been permitted to accumulate private endowments for the same amount (about US$5,000 per student). Ihese figures should be contrasted with the figure of US$400,OOO per student enjoyed by Harvard. Even if Harvard is an exceptional case, the fact remains that there are tremendous differences in financial resources, even for Indian "centers of excellence," compared to true research universities. Until this is rectified, India cannot expect to make much progress in higher education.


Some [members of the Parliamentary Committee on Scheduled Castes] feel that our standards are too high. Some members have gone so far as to say that what we need is an Indian standard and not an international standard of in- struction.... It is necessary to debate the fundamental question whether, just because a group of people cannot cope with a certain level of education, they should have the veto power to deny such an education to the rest. (Indiresan and Nigam 1993, 358)
World Class Worldwide: Transforming Research Universities in Asia and Latin ...

edited by Philip G. Altbach, Jorge Balán
inderesan
.Universities generally perform three functions. At the most basic level, they impart knowledge derived from the past to a new generation of students: they teach.
 At the midlevel, they critically apprise past knowledge and distill its essence: they produce textbooks. 
At the highest level, they expand the frontiers of knowledge mainly by minute analysis: they do basic research. 
A few universities make breakthroughs, open completely new vistas of knowledge, or create knowledge revolutions, leading at times to new kinds of industry. A world-class research university may be described as one that sup- ports teaching and research, preferably but not necessarily covering a wide range of disciplines (from the arts and humanities, to the social sciences, and science and technology);' retains the freedom to decide autonomously what to teach, who will teach, and whom to teach; attracts students and recruits faculty from all over the world; and earns international honors lik
Except for those who are genuinely interested in teaching, the teaching profession has come to be viewed as a career option by those who find themselves unfit for other professions.

The results of the Central Teacher Eligibility Tests (C TET) conducted by the Central Board of Secondary Education (CBSE), declared on 27 December, 2012, showed that less than 1% of the 7.95 lakh candidates who appeared for the examination passed The C TET comprises two papers. Paper I is for aspirants wishing to teach classes 1-5 and Paper II for classes 6-8. Clearing C TET is essential to teach in any central government school. Delhi government uses CTET for recruitment of teachers for govt-run and aided schools.

In the C TET conducted in 2012, of the 2.71 lakh candidates who appeared for Paper I of C TET, only 2,481 passed. Of the 5.24 lakh candidates who appeared for Paper II, only 2,368 passed. In fact since the examination was introduced in 2011, the pass percentage has been declining. This situation is a "wake up call" for the quality of B.Ed. degree being awarded. This being the real background it is not surprising that the trainee teachers would often get stumped by some students in schools during their training period.

With the advent of internet the students are well informed and the teachers remain far behind. Today's children are digital natives and we, teachers, are digital immigrants. That sums up the gap between students' and teachers' understanding of electronic gadgets and being net—savvy. Many companies and private organisations are targeting schools to provide technology based lessons, lesson plans and assessments. Students in high profile schools bring lap tops or iPads to the classes. Some elite schools provide LCD projectors in every class rooms. It is left to the provider of these facilities to train the teachers. How many B.Ed. colleges have undertaken to make their teachers techno savvy? The schools and B.Ed. colleges do not keep pace with the current developments but function in isolation.

The B.Ed. course trains the teacher to be entirely student— centric. Some of the methods taught in the B.Ed. course may be idealistic but not difficult to practise. After passing the ideal B.Ed. course, once a teacher joins a "real" school the focus shifts from teaching students to "practical considerations". Most of the teachers unlearn what they were taught in the B.Ed. course. There is a huge gap between theory and practice which reduces the B.Ed. course to a mere formality.


Over the years the Reservation Policy has been used more to achieve political ends rather than for up Of the under privileged. It is used by the politicians to create and maintain 'Vote Banks'. Without a total reform in the Electoral System Of the country this policy will remain Only as a tool in the hands Of politicians to attain their own ends. Reservation policy is like treating the symptoms of a social evil, not its remedy. Remedy is to elevate the educational, 60 intellectual and economic level Of the underprivileged by education and instill confidence in them to compete with others as equals.



Its systematic disinvestment in higher education in recent years has yielded nei- ther world-class researchers, nor very many highly trained scholars, scientists, nor managers to sustain high-tech development.... India's colleges and universities, with just a few exceptions, have become large, underfunded, ungovernable institutions. At many of them, politics have intruded into campus life, influencing academic appointments, and decisions across levels.... India's best universities require sustained state support landl they also require effective management and an ethos of academic meritocracy. At present, the structures are not in place to permit building and sustaining top-quality programs even if resources are provided. (Altbach 2005)

In India, as a reaction to age-old discrimination against lower castes, social and political pressures have grown against elitism. Draconian legal measures favoring lower castes and stringent restrictions on the admissions and recruitment of students belonging to upper castes have become an impediment to the pursuit of excellence. The problem is aggravated by political and bureaucratic interference, not merely regarding academic issues like student admissions and faculty selections but even in petty purchases. Such micromanagement takes away all freedom and destroys vitality within the system. Paternalist and authoritarian traditions of Indian culture have led to the existence of autocratic administrations that insist everything has to be done according to rules or precedence, with little or no scope for innovation. That authoritarian culture affects student attitudes, too; students tend to accept what is written down without a questioning mind. Hence, Indian students exhibit commendable skills in applying exist-

students tend to accept what is written down without a questioning mind. Hence, Indian students exhibit commendable skills in applying existing rules to produce optimal designs, but they are uncomfortable about questioning the rules themselves. They suffer from economic pressures as well. Their need to get out of poverty is so great that they are mainly interested in studies that lead to lucrative careers as opposed to scholarship. As a result, not many Indian students make good researchers. Financially, too, Indian universities are in poor shape. Even the much- pampered IITs have an annual budget of about US$20 million (I billion rupees) each, about US$4,000 to US$5,000 (150,000—200,000 rupees) per student each year. Even after factoring in the much lower salaries in India, the funds are a small fraction of what most universities in the world command. Although they enjoy more autonomy than most other institutions
in the country, IITs are not allowed to accumulate endowments in excess of US$20 million. Thus, Indian universities enjoy only one (brilliant students) of the four factors mentioned above as essential for the success of a research university.

Pounding peasants from 3 kilometers up is not exactly an ideal way to occupy the moral high ground in war.

Pounding peasants from 3 kilometers up is not exactly an ideal way to occupy the moral high ground in war.

The US cult of bombing and endless war
William Astore
By WILLIAM ASTORE in Asia times

How come  not a single  presidential candidate  or  a single TV commentator says anything  about the  longest  /18+ years war in Afghanistan?
Is it because  none  of  the  powerful people in Washington  are  affected .

Bring  back the  Draft I say

Who doesn’t know the old riddle: If a tree falls in the forest and no one is there to hear it, does it make a sound? Here’s a 21st-century air power variant on it: If foreign children die from American bombs but no US media outlets report their deaths, will anyone grieve? Far too often, the answer here in the US is no, and so our wars go on into an endless future of global destruction.

Don't fall in to the trap of western rhetoric of liberal education.

Don't fall in to the trap of western rhetoric of  liberal education.
 The latest  Draft of indian educational policy is a topic of contention because of the old dravidian  resistance to imposition of Hindi.
As expected even BJP will back track on the 3 language policy mainly because they never  believed in it and it  was never implemented in Northern states only in erstwhile Andhra pradesh during  60s and 70 s this was really implemented in earnest.

but more than this the so called lofty ideal of  adding liberal education to professional education  is should be the  main topic of discussion.

American Students drop ou  of the education stream at high school and undergraduate level and   have to import immigrant doctors  and engineers  mainly due to this importance given to " Liberal education"

Let us not fall in to this trap/ let us not burden the  parents and students with yet another year of wasted time and money. keep the  professional education sharply instrumentalist

we will get to learn the meaning of the  convoluted  paragraph by an English professor

The unwitting subtext of the bitter conflict between the liberal university and anti-liberal nationalism around the world has often been that between an expansive humanistic education and a sharply instrumentalist one. The proposal of mutual symbiosis between professional and liberal education in the draft of the New Education Policy hints at some possibilities of resolution.

This year's Highest award in India goes to EVM machine !

First, let us address the tool of elections — the Electronic Voting Machine (EVM). Aspersions were cast on its integrity, and by implication, on the whole election machinery. Some people even argued for a reversion to the paper ballot, jettisoning decades of reform in the conduct of elections. Questions were raised on the statistically correct sample of Voter Verifiable Paper Audit Trail (VVPAT) machines to be counted for certainty of results. The matter went up to the Supreme Court, which ordered a mandatory count of five randomly selected VVPAT machines per assembly segment. In smaller states like Mizoram, it amounted to nearly a fifth of machines being validated. The results were astounding. In over 20,000 counts, there wasn’t even a single instance of mismatch between the EVM and VVPAT count. This wasn’t just an endorsement of the humble EVM, but also a tribute to the 12 million officials engaged in the conduct of elections. It should be a matter of pride for all Indians that no nation has taken a bold leap of faith in venturing into the use of such machines for elections at such a scale.

The degree and nature of electoral reforms will require wider debate and political consensus. The EC can be an enabler of this dialogue, which must embrace not only the processes required for ensuring greater fairness in the conduct of elections but also transparency in electoral funding, measures to curb the use of money power. In the meantime, let us not sully the reputation of institutions or question the hard work of millions of officials who work tirelessly for their national duty. For all the doubting Thomases, let us lean on the words of Charles Dickens: “Men who look on nature, and their fellow-men, and cry that all is dark and gloomy, are in the right; but the sombre colours are reflections from their own jaundiced eyes and hearts.”

Debate electoral reforms, but refrain from sullying the reputation of institutions.
Written by Ashish Kundra |

Published: June 7, 2019 12:29:07 am
are! Pappu samaj gaye na !
अरे पप्पू  समाज गये ना !

Yet another case of sour grapes


Lessons from the verdict
The idea of India may have lost its political currency.
Written by Ravinder Kaur |
Published Indian express web edition : June 7, 2019 12:24:37 am


The (Indian) people have been merely hoodwinked through a dazzling spectacle produced through unfair means. A part of this belief is correct — the BJP’s media machinery oiled by nearly unlimited funds is without parallel in the history of contemporary India
 ( Are you telling me Congress  with all it's corruption  is poor ?)


That the party does not hesitate to forge a victory through all available means is too well known.

 You mean to say other parties don't ?

But the thing about ideas is that they can be unmade and made. This impermanence is precisely what opens up the possibility of new political imagination. The first step is to recognise that, this time round, the idea of India may have lost its political currency.

 For a person living in  Copenhagen this Author only needs to read about the  history of the country he is living in,to understand
  Things change.

Visceral pain

mandala medicine

Although the existence of topographic maps is well accepted and highly developed with respect to the primary sensory systems and somatomotor pathways. the establishment and acceptance of a sensory and motor viscerotopy for parasympathetic innervation of visceral structures are relatively recent. Earlier work was either contrary to the idea or ambivalent in its conclusions. With the arrival of better neural tracers and strategies for controlling spread at injection sites, data emerged supporting a viscerotopy for particular viscera innervated by the glossopharyngeal and vagal nerves. We found a dramatic representation of the stomach in the nucleus of the solitary tract (NTS) which spurred us on to further study. Viscerotopy was also reported in the pigeon. to Columns were identified in the dorsal motor nucleus of the vagus (DMV) and correlated to vagal branches which were potentially organ specific. nucleus ambiguus in the rat was shown to be viscerotopic in its motor innervation of the upper alimentary canal. Our work was aided by the use of a very sensitive tracer which transports retrogradely to motoneurons, fills out their dendritic arborizations beautifully and passes transganglionically to anterogradely fill out central terminal fields of sensory neurons. The tracer is cholera toxin conjugated to horseradish peroxidase which we prepare ourselves.' In our experience it is more sensitive than HRP alone, wheatgerm agglutinin alone or conjugated to HRP. or any fluorescent tracer. Much Of its sensitivity is attributable to its receptor binding affinity for GMI ganglioside which occurs in neural membranes. This feature also aids in reducing the spread of the tracer from the injection sites and permits the use of concentrations of tracer which are nearly an order of magnitude below those used for other tracers.


for GMI ganglioside which occurs in neural membranes. This feature also aids in reducing the spread of the tracer from the injection sites and permits the use of concentrations of tracer which are nearly an order of magnitude below those used for other tracers. The main focus of our own research has been on the vagal and glossopharyngeal in- nervation Of the structures of the alimentary canal. This chapter describes our current knowl- edge of the topographic representation of several of these viscera (including the soft palate, pharynx. esophagus, stomach, pancreas. cecum, and intestines) in the dorsal and ventral vagal complexes in rats. The majority Of these observations were made following injection of the neural tracer cholera toxin-horseradish peroxidase conjugate (CT-HRP) into various viscera and histological examination of subsequent anterograde and retrograde neural labeling in the medulla oblongata. For detailed descriptions of nrthodology and control procedures, the reader is referred to our prior published reports: Shapiro and Rinaman and Rinaman et al.;lS Altschuler et and Ferenci et al. We will review the highlights of these reports and refer you to the original papers for greater detail. 11. VAGAL SENSORY VISCEROTOPIC ORGANIZATION The vagus nerve is a truly mixed nerve; its afferent component contains general somatic, special visceral (taste), and general visceral sensory fibers while its efferent component contains general visceral efferent axons that are yna ic to autonomic motoneurons

sensory changes have also been seen in the corresponding "viscerotome" [28]. Such changes in localization and sensi- tivity of the referred pain areas may be a hallmark of dis- eased organs and if the experimental methods are improved they may serve as a biomarker of the disease. Viscero-visceral hyperalgesia is a complex form Of hypersensitivity probably explained by more than one mechanism. Since this phenomenon takes place between visceral organs which share their central afferent termina- tion, it is plausible that central sensitization plays an impor- tant role [29]. Recently, human experimental studies support the role of viscero-visceral hyperalgesia in GI diseases. Acidification of the distal esophagus resulted in hyperalge- sia in the proximal esophagus, and duodenal acidification was shown to induce esophageal hypersensitivity [30]. Recently, we showed that acidification of the esophagus in healthy volunteers involve widespread changes in the per- ception of experimental pain from remote organs such as the rectum [31]. The widespread visceral hypersensitivity in functional GI disorders (IBS, functional dyspepsia, etc.) may be due to this mechanism. As an example a marked reduction in colonic perception thresholds and alternation in the viscero-somatic referral pattern were seen in patients with IBS after lipid administration in the duodenum [32]. Vlscerovisceral hyperalgesia may also explain the epidemiological findings in several clinical conditions with organic diseases such as an increased number of anginal attacks in Patients with gallbladder calcinosis. and increased diseases, e.g., in patients with gastroesophageal reflux dis- ease (GERD) where increased sensitivity to gastric distenSion was shown. Therefore, the frequent airway symptoms in GERD (often refractory to treatment with proton pump inhibitors) may not only be related to direct aspiration of the gastric refluxate, but vasovagal reflex mechanisms evoked by acid-related hyperalgesia may also be important [34]. Repeated stimulations: Sensitization of the spinal neurons is known to occur with prolonged or repeated stimulation ("wind-up" or temporal summation) of the peripheral afferents. Thus, temporal summation results in a short-lasting spinal cord sensitization that persists after discontinuing the peripheral stimulation. In the laboratory, this is perceived as increased pain to a series of stimuli with the same intensity. Repeated electrical or mechanical stimuli to the small and large intestine in volunteers may cause increased sensation to subsequent stimuli, and this may be used as a model for enhanced central gain [1—3]. In functional pain Munakata et al. showed the importance of central mechanisms. In their study, patients with IBS developed rectal hyperalgesia following repetitive sigmoid distensions [35]. Paterson et al. [36] as well as studies from our group [4] also showed that repeated distensions conditioned the esophagus in functional chest pain patients resulted in higher pain scores. In organic diseases, repeated stimuli were also used to show the central amplification of pain in patients with chronic pancreatitis [371. 


Your first patient of the day

Your first patient of the day is a successful person in the community. She is admired by her friends and colleagues, respected by her coworkers and staff, and loved by her family. She came in to see you today because she is tired and restless and has multiple minor aches and pains. She also doesn't have the energy that she had a few years ago. On your evaluation you find that she is working many more hours than she used to, she is not spending time with her family, and although she understands exercise and healthy nutrition, her diet and exercise program is somewhat lacking. On further questioning, you gain a sense that she is type A with modest anxiety. She has a pressure to succeed and a need to be seen by others as successful and caring. This leads her to overwork, lack in selfrcare, and lack in connection with others. Does this patient sound familiar? This patient is representative of most midcareer physicians. What would you recommend to this person? After ruling out any significant underlying disorder, it is likely that you would recommend a lifestyle change program, including the following: Optimizing physical well-being Optimizing emotional well-being Optimizing mental well-being Optimizing spiritual well-being The first step is to realize that this patient is worth the effort! Why do all this work? Maybe you feel that you don't deserve to take the time needed to be healthy. Maybe you feel that that would be a self-centered approach to life and medicine. To put it bluntly, dead doctors serve no one! If you are to be a healer, you must begin the process of healing yourself, learning from your mistakes, and then teaching from this experience of trial and one, do one, teach one." It is no use walking anp•.'here to preach unless our walking is preaching. St. Francis of Assisi The physician is a teacher. The Latin root Of the word doctor translates to "teacher." We are teachers of infor- mation. Ideally, we serve as a stable guide and resource to our patients and community, and we teach by example. Nowhere in medicine is the concept of teaching by example more important than in the practice of integrative/holistic medicine, where life balance moves the individual toward the goal of optimal health. Our personal presence and sense Of self affects our interactions with our patients and also affects our

patienfi outcomes. If we are agitated, rushed, and acting out type A tendencies in our office, our patients will see this and have no apparent resource for managing these issues themselves as they attempt to modify their lives. If we can be self-aware and working on these issues ourselves, then we can serve as teachers to our patients, our partners in health. To put the world right in Order, we must first put the nation in order; to put the nation in order, we must first put the family in order; to put the family in order, we must first cultivate our personal life; we must first set our hearts right. Confuci us Creating your Own Health Plan How can we physicians gain a reasonable sense of life balance and therefore be better teachers to our patients? First, one must realize that life balance is a process, not a goal. One day you may feel as if you've "got it" and then something unexpected occurs, throwing you into imbalance once more. Perfection is not the goal either. The belief that one can be in perfect health, without medical or evaluated; however, a few studies have been done. We smoke less, exercise more, and eat healthier than our patients, yet our overall mortality is not much better than any other professional group. Our per-capita rates Of heart disease. depression, and stroke are higher than any other working group.'._. Although earlier data on physician mortality are a bit frightening, more recent data suggest that our overall mortality is improving. We now live roughly 5 years longer than other professionals. When put in perspective of our better exercise, nonsmoking, leaner body mass, our self-care knowledge base. and healthy eating, this doesn't appear to be a substantial difference. • One of the missing health pieces for us may be our high rate of stress and depression, which enhances cardiovascular mortality.' As most readers will be aware of the physical aspects of life and health, I will not say much about them here except to mention that they include nutrition, exercise, body work, stretching, and physical pleasure. One part of physical well- being that deserves special mention is sleep. Jt is reasonable and important to get enough sleep on a near-daily basis. Without this, life balance becomes difficult, and our health suffers as well. Physicians are often sleep deprived.

then Jomething unexpected occurs, throwing you into imbalance once more. Perfection is not the goal either. The belief that one can be in perfect health, without medical or emotional issues, at all times, throughout life will lead to disappointment. True balance involves trying and failing, learning from error, and finding new ways of enhancing well-being. The process Of balance includes paying attention to the four key areas of your personal life and development: (l) the physical, (2) the emotional, (3) the mental, and (4) the spiritual. The more balanced we are, the healthier our relationships will be. If we live a life of healthy relationships where our emotional needs are met, we can approach our work with our grace, humor, and values intact. The creation of life balance brings us closer to our own optimal health. The American Board of Holistic Medicine defines optimal health as The conscious pursuit of the highest level of functioning and balance of the physical, environmental, mental, emotional, social, and spiritual aspects of human experience, resulting in a dynamic state of being fully alive. This creates a condition of well-being regardless of the presence or absence of disease. With this in Copyfish Our Emotional Well-Being Our emotional stress or distress is one Of the primary causes of our life imbalance. Conversely, emotional well-being is one of the strongest antidotes to life imbalance. Much of our emotional imbalance Can be rooted in Our personality structure. It is often less about what we are doing than how


The conscious pursuit of the highest level of functioning and balance of the physical, environmental, mental, emotional, social, and spiritual aspects of human experience, resulting in a dynamic state of being fully alive. This creates a condition ofwell-being regardless Of the presence or absence of disease. With this in mind, let's proceed to look at the four key areas Of life balance in an average physiciar* life. Our Physical Well-Being What is the state of physical well-being Statistics on physician health are only for physicians? recently being Well—Being Our emotional stress or distress is one of the primary causes of our life imbalance. Conversely, emotional well-being is one of the strongest antidotes to life imbalance. Much of our emotional imbalance can be rooted in our personality structure. It is often less about what we are doing than how we are doing it. This personality structure is well in place before our first day of medical school, and some of the more problematic aspects of this structure are made worse through our medical training. The psychological make-up of a physician-to-be is most interesting and Often problematic. We are people oriented, intelligent, caring, inquisitive individuals. This is a natural fit with our intended careers. We are also type A, perfectionist, and competitive. Although these are not considered, by most, to be positive attributes, it would seem to be extremely difficult to survive the current structure of medical school and postgraduate training without these qualities. We also tend toward social isolation. Many Of us are shy or quiet and a bit "nerdy" as well.



Individuals attracted to a career in medicine also tend to be safety seeking or change averse. This was one of the attractions of medicine 20 years ago. Medicine was a stable career path. We now know this to be untrue; medicine has changed dramatically over the last few decades and Will continue to do so. For the change averse, change increases anxiety. •rhis has been a daily reality for many physicians over the past 20 years. Our awareness Of change does not mean that we have learned flexibility. Our inflexibility and resistance to change leaves us frustrated and anxious about our futures. Medical Training Our type A, perfectionist, and «»mpetitive attributes are enhanced during our schooling/training process. Fear of failure enhances type A and competitive behaviors. Fear Of error enhances perfectionism to obsessive levels (yes, we are dealing With serious issues. but obsession is healthy for no one). Social isolation is increased with our long hours and exhaustion. And learned emotional dissociation, to be objective, tends to shut down our compassion. By the time we are ready to enter practice, we are exhausted. isolated from family and friends, in debt, nontrusting, egocentric (the expression of insecurity), and emotionally dissociated (numb). This does not make us healthy physicians, not be true tomorrow. This brings average hit rate down to 50%. If you add the fact that we are fallible and that there are variances for response to treatments, you may be correct to Of the time. Don't feel bad—in baseball, the greats have a batting average Of less than 40%, so you are still up there! Where this becomes a problem for us is that we chastise ourselves for these errors. We worry and hold anxiety about them for years. I still feel anxious about misdiagnosing a patient With testicular cancer that fortunately was caught by a colleague. That was 13 years ago! Generally, we have no one to discuss these mistakes With. We are afraid to talk to our coworkers because we don't want to be seen as imperfect and We know We'll be judged. We don't want to trouble our spouses With this informa- tion in that they "may not understand" or we may fear their iudgment as well. Often, What is behind this is our own insecurity. The underlying question is, are we good enough? If wc can't be imperfect, this disallows patients their own imperfection, and they feel to less than human. Imperfections. our own flaws, are sometimes our greatest teaching tools. Where did this perfectionism come from? Much of this behavior is learned from our parents. In a personal com- munication, Rachael Naomi Remen, a wonderful physician and author. described a scene from her childhood. She recalled coming home to her father With a test score Of 98 and excitedly telling him about it. His response was, "What



the teachers of optimal health. Perfectionism Why bother to look at this issue? Isn't it better to be perfect? Expecting perfection is a fallacy when one is living a life Of constant change, working With a population that Will sometimes follow your instructions in a system that can only sometimes fill your needs and the patient' needs and teaching a science filled with gray mnes of understanding. "Good enough" may be all you get. Beyond this, "perfect" is truly an artificial construct. R•rfectionism is extremely common among our colleagues. It is excused or even supported because we often deal with issues. This fosters the belief that mistakes are inexcusable. If a physician is imperfect, he or she is a bad physician. Yet we are all fallible; we all make mistakes, as do the rest of the humans on the planet. This paradox can create significant stress for us. If you see 25 patients daily, 5 days a week (for many Of us, it's more), 48 weeks per year for 30 years, that' 300,000 clinical decisions made. (How many of you perfectionists checked my math?) NOW When you consider that we usually multitask and make clinical decisions outside of work as well, the number ows substantiallv. With this in mind what happened to the Other two points?" encapsu dynamic Of perfection perfectly! As children we want to please our parents. Depending on the existing relationship, this need can be driven by seeking love and support, or it may be driven by avoiding discomfort. Our parent may hold lofty goals and expectations for us and often believe that it is in our best interest to "go for the gold." The belief that shooting for the stars will facilitate our doing well even if we fall slightly short Of this goal is prevalent in our country. On a superficial level this may seem viable; however, look at the effect of the simple interaction described earlier on a young child. The child is excited by her achievement. If she receives support from her father, she would be motivated to continue this good work. as it serves her goal of feeling loved and validated. She vmuld develop a healthy self-esteem and would continue to learn without anxiety. She would also be likely to have greater self-confidence and creativity. She would then bring this into other relationships in her adult life. In the scenario presented earlier, however, the child learns to question her own validity and thus feels insecure. She also learns to seek her father's love and support by pushing herself harder. As no child is perfect, there will be Other less than perfect academic and goal outcomes and therefore continued disappointments. As B. F. Skinner showed With his trainin Of rats intermittent atifi-


it's more), 8 weeks per year for 0 years, that's clinical decisions made. (How many of you perfectionists checked my math?) Now when you consider that we usually multitask and make clinical decisions outside of work as well, the number grows substantially. With this in mind, what is the likelihood that one of 300,000 decisions was the wrong one? The dean of the medical school at the University of Toronto once told his incoming class that "half ofwhat we teach you in the next 'l years is wrong, and the problenl is, we don't know which half." How can this be true? Medicine is always changing, and therefore what is "true" today may 44 MEDICINE This is judgmentalism, not often perceived as a positive quality. One way that this process becomes manifest is the seeking of socially significant goals, such as choosing career that is difficult to obtain, rigorous to live, socially admired, and financially rewarding. Sound familiar? This would be a less harsh, socially acceptable manifestation of the She also learns to seek her father' love and support by pushing herself harder. As no child is perfect, there will be other less than perfect academic and goal outcomes and therefore continued disappointments. As B. F. Skinner showed With his training Of rats, intermittent gratifi- cation is the strongest way of facilitating reward- seeking behavior. This child will become an adult who pushes herself hard toward perfection and rarely, if ever, is satisfied with her performance. This will adversely affect her adult relationships because she, too, will expect perfection of others and be critical of their performance. Copvri0htcxS ask questions and concede when you didn't have the answers. Not knowing was alright and encouraged. You presumed the adults had the answers. In your early teens you probably heard, "you are old enough to know better," This attitude was reinforced throughout your youth to the point of embarrassment if you did not know an answer. Medical training only made this worse. On



One way that this process becomes manifest is the seeking of socially significant goals, such as choosing a career that is difficult to obtain, rigorous to live, socially admired, and financially rewarding. Sound familiar? This would be a less harsh, socially acceptable manifestation of the drive to please. Many of us choose medicine to please our parents. 'Chis may be at a deep or subconscious level, but I ask you to consider this in your own choice of career. It is a lot of Work to have done to gain approval from your parents! Our parents are not the only ones whose approval we seek. We seek the approval of our mentors in our training and even our patients. In a simplistic way we want to be perceived as perfect. If perfection were obtainable, this might be a good goal; however, as we all make mistakes, none of us will ever achieve perfection, and many of us will remain unsatisfied with our performance and ourselves. How sad. I would choose to be happily imperfect any day of the week; it's much less stressful. Just acknowledging your imperfection will be freeing for you. I am not saying that you should give up the concept Of "bettering" yourself. This would lead to stagnation. I ask that you accept that the goal is to be better, not perfect. If the goal is "perfect," you can't win! Keep in mind that trying to live up to others' expectations Of you is a way of allowing them to control your life. Many Of us came to this in our teen years—rebellion is the out You presumed the adulVs had the answers, In your early teens you probably heard, "you are old enough to know better," This attitude was reinforced throughout your youth to the point of embarrassment if you did not know an answer. Medical training only made this worse. On rounds or in morning report, it was unacceptable to not know an answer, and you were made to feel inadequate if you didn't know; thus, the generation of anxiety about not knowing the answer to any question asked of you. At this time in your life, learn to say, "l don't know, but if you'd like I can find out for you." You will feel less pressure and the people you serve will appreciate your integrity and your desire to serve them. Not a bad tradeoff for a little imperfection. The Need to Be Needed: Care Addiction Doc Lew Childre and Howard Martin, in their book, The Heart,Vfarh described a state of emotion being common among physicians as the State Of Overcare is caring run amok. When you care ror someone, it is energizing. When you are cared for, this too is energizing. However, When you overcare, it is energy depleting. Have you ever sat up at 3:00 AM worrying about a




expectations of you is a way of allowing them to control your life. Many of us camc to this in our teen years—rebellion is the outcome. Take back your personal power; choose your own goals, not those held by Others. Anything worth doing is worth doing half-assed. Rachael Naomi Remen, M D Other expectations we try to live up to may be social. For example, if you were married during your training, your spouse lived through a lot of difficult times. You may feel obligated to "pay back" the spouse With a nice house, car, travel, and so forth. Although this appears to be valid on a social level, it may not be working for you. If you feel overworked because you are trying to do good things for your family—to be the provider—you may want to ask them if they would prefer more income or more of your time. You may be shocked to find out that the time spent you is more important than a new car or vacation, but you won't know until you ask. You can't ask for a more honest authority than your kids. Perfectionism also leads us to judge ourselves harshly. This may be the most detrimental of all judgment. If we cannot achieve perfect outcomes, we tend to beat ourselves up for it. We become our harshest and most persistent critics. The problem is We don't know how to let go. We hold the be Copyfish However, when you overcare, it is energy depleting. Have you ever sat up at 3:00 AM worrying about a patient?s diagnosis or a treatment decision you've made? Docs this serve you or the patient? NO. It is draining. You Will have less energy the next day, and you will have done nothing to serve your patient. Your own fatigue may be a disservice to them. '1%is is overcare. The true emotional energy keeping you awake contains a of "rounds fear" and the question "Am I a good enough doctor?" Perfectionism in action! Not only do wc overcare, but wc are also addicted to being needed. We often get love from our patients in many forms. A patient Of my Wife recently called at 7:00 AM to tell her that his mother had made dumplings the night before and he wanted her to have some While they were fresh. Although 7:00 was not terribly convenient, the patient had gotten up early, before work, to bring the dumplings to my wife. Not knowing where we live, he called from the parking lot of a nearby market. Moments like this, When a patient says thanks and goes out of his way to show you appreciation, arc the "highs" we get as physicians. We feel valued, we feel like we are enough, and we feel loved. The problem is, that this is a form of intermittent gratification. We spend so much Of our day feeling undervalued that we look for the "love" from our patients and don't often get it. We are then led to extend ourselves



obligated to "pay back" the spouse with a nice house, car. travel, and so forth. Although this appears to be valid on a social level, it may not be working for you. If you because are trying to do good things for your family—to be the provider—you may want to ask them if they would prefer more income or more of your time. You may be shocked to find out that the time spent with you is more important than a new car or vacation, but you won't know until you ask. You can't ask for a more honest authority than your kids. Perfectionism also leads us to judge ourselves harshly. This may be the most detrimental of all judgment. If we Cannot achieve perfect outcomes, tend tn beat ourselves up for it. We become our harshest and most persistent critics. The problem is We don't know how to let go. We hold the belief that the more we push ourselves, the more likely we are to succeed in our goal toward perfection. As perfection is illusory, we will spend the rest of our days beating ourselves up. What a waste of time and energy! Learn 10 your imperfect. Learn from any you make. Apologize if needed, and move on. The inability to admit not knowing an answer is a learned behavior. As a young child, you Were encouraged to many forms. A patient of my wife recently called at 7:00 AV to tell her that his mother had made dumplings the night and he Wanted her to have While they Were fresh _ Although AM Was not terribly convenient, the patient had gotten up early, before work, to bring the dumplings to my wife. Not knowing where We live, he called from the parking lot Of a market. Moments like this, when a patient says thanks and goes out of his way to show you appreciation, are the "highs" we get as physicians. We feel valued, we feel like we are enough, and we feel loved. The problem is, that this is a form of intermittent gratification. We spend so much of oar day feeling undervalued that We 100k for the our patients and don't often get it. We are then led to extend ourselves and often spread ourselves too thin to be appreciated. In the language of the addiction world, this is codependency. You are so busy caring for others that you no longer take care of yourself. The solution to this way of being is one of the most tasks known humans, to to yourself enough to kncnv that you are enough. If you come close to this, "'u no longer need external validation to get your "highs."


Our Mental Well-Being Our learning and mental growth are critical to our survival. Physicians enjoy learning. We enjoy science. Allow yourself to cnioy learning again. Denying oursclvcs this opportunity Creates tension Causes a Sense Of Stagnation. Set aside one uninterrupted hour per week to read the literature. At a nunimum pu will decrease your guilt and the size of the pile your and you might a better clinician for it! In addition, allow yourself the time to learn about subjects outside of medicine. such as art, history, and music. This allows for an enhanced sense of personal growth and development. Another key to well-being is to learn to say "I don't know." We are taught, through adverse conditioning in residency, never to utter these words. but in these days


of massive information availability, you can't know everything, This is especially true in the realm of integrative and holistic medicine where the world literature is massive Of various degrees Of scientific rigidity and information is readily available on the Internet. What is healthy response? Tell your patients you will find out the answer for them. 1.00k up the information (the Internet great for this) and have a staff member e-mail or phone the patient. helps you avoid a lengthy followup call, and you learn something rlcW in the process. This is great patient service!


Our Spiritual Well-Being For many of us, a sense of spirituality becomes our energy source. In Frank's study of women physicians,' she found that those women who had a religious or spiritual life were happier in their work life than those who did not. Spirituality and religion are not always connected. In a simple way spirituality is a sense of connection with something greater than yourself. This can be your family, your community, your your The bottom line is that you do not perceive it "all" as being about you. This is where work of service in medicine can truly blossom. Medicine is, after all, service, not serving. For many integrative-holistic practitioners, spirituality is the one of the mainstays of their personal balance. This is often into our lives in Of religion, meditation, yoga, or other pursuits afwell-being. Others may feel that spirituality is not important to the patient or themselves. However, of people believe in a higher being, uf patients regard their spiritual and physical health as equally important, and of family practitioners belie.'e that spiritual well-being is a factor in health.o More than 800 studies worldwide have shown that when individuals have Sense Of spirituality religious they have better physical health outcomes compared with those who do •rival. not have these qualities in their lives: Irself


Connect with the People in your Life Deep connection with others leads to a greater sense of humanity and a richer sense of a "larger meaning," It also enhances the Support receive in and decreases the social isolation you may have been experiencing. Deep personal connection also improves your personal health' A sense of true connection With others, especially those whom you serve, takes you out of the mode of physician and



brings you to the level of human helping human. •II-ais state is where healing can begin for both of you. Only thing I that truly heals people is unconditional love. Elizabeth K Obie-Ross, M D is especially true at home. Don't answer the phone during meals (except when you are on call). Shut off your and When you are With your family. The world will not fall apart without you—you are not that essen tial! Remember to Love We and need to and be Remember how gratifying it is when a patient gives you sincere thanks or a gift for the work you've done. If give more love, you Will receive morc love. If you come from a loving home environment, the "little" things at work will Stay little. is not how you but put into the doing that matters. Mother Teresa


your Monthly Health Plan Log  Shown in fig use it  track health plan. Post it somewhere obvious so you keep track. List all activities, no matter how minimal—perfection is discouraged! 


A south American Poison plant and Old age Muscle wasting the unusual connection

TOXICOLOGICAL AND PHARMACOLOGICAL STUDIB ON THE POWDERED STEM OF RYANtA SPECIOSA, A PLANT INSECTICIDE SAMUEL KUNA RALPH E. HEAL TecnxtCAL FRANK CUCKIE Jutit•tt for and tit neeived publication 12,

 As early as 1922, invetigators (1, 2) connected with the Brazilian Commercial Mtnum became interested in certain specie of the genus "Ryania" (Flacourti- These investigators as well as Nakarai and Sano ot Japan (3, 4) and Mera (5) of Germany were primarily interested in the highly toxic extraction of  cyanine and ryanitine, which they as the active principle






 This article is more than 8 months old
Brazil National Museum: as much as 90% of collection destroyed in fire
 This article is more than 8 months old
Building was not insured, the museum’s deputy director said, but some pieces survived including the Bendegó meteorite

Dom Phillips in Rio de Janeiro

Tue 4 Sep 2018 13.31 EDT Last modified on Fri 7 Sep 2018 06.02 EDT
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 Huge fire guts Brazil's 200-year-old National Museum - video report
As much as 90% of the collection at Brazil’s National Museum was destroyed in a devastating fire on Sunday and – compounding the disaster – the building was not insured, according to the museum’s deputy director.

Some pieces survived, including the famous Bendegó meteorite and a library of 500,000 books – including works dating back to the days of the Portuguese empire – which was kept in a separate annex, Cristiana Serejo told reporters in front of the building’s blackened shell.


Brazil National Museum blaze in Rio blamed on austerity
 Read more
But it was still not possible to say how much of the collection had escaped the flames, Serejo said. “It could be 10%, it could be 15, it could be 20,” she said. “We had a very big loss.”

The museum’s Egyptology collection was completely destroyed, Serejo said.

Researchers who were able to enter one area of the building in Rio de Janeiro are starting to catalogue what little is left, said Serejo, who appealed to members of the public to return any items they found.

Asked if the museum was insured, she screwed up her face in mock anguish, and shook her head.

“I hope we learn from this,” she said. “Other public buildings are in the same situation.”

Two days after the museum was gutted in a fire that has traumatized Brazil, smoke still rose from the wreckage, and small fires are still breaking out, said a firefighter who declined to give his name. “It’s wood that is still burning. We are constantly throwing water on it.”

 An aerial view of the museum on 3 September.

 An aerial view of the museum on 3 September. Photograph: Buda Mendes/Getty Images
The scale of the destruction was clear: although the museum’s smoke-charred exterior walls are still standing – and statues still gaze out over the Quinta da Boa Vista park, little could be seen inside but piles of rubble.

Firefighters combing the wreckage on Tuesday found some bones and fragments of a skull, sparking hopes that the museum’s centerpiece – a 12,000-year-old skeleton known as “Luzia” – may have survived.

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“Obviously we would love it to be Luzia but we can’t confirm this,” said Fernanda Guedes, a spokeswoman, adding that the biological anthropology area where the fragment was found also housed dozens of other skeletons.

Some porcelain and paintings have also been recovered from the ruins.

On Tuesday morning, there was a scuffle of excitement around Felipe da Silva, 29, a security guard who had found a burnt page of a book near the museum.

TV cameras and reporters jostled for pictures of the page – a text in English about Paleolithic and Mesolithic populations in Turkmenistan.

“It is an inexplicable feeling to be able to deliver something that stayed intact in this destruction,” Da Silva said.

The building has been sealed off to the public by crash barriers – some of which bore the name of Rio’s tourism agency Riotur. 


Brazil's national museum: what could be lost in the fire?
 Read more
Notes of protest had been taped to some of them. “A society without culture and research is a failure,” was written on one. 

Yet while anger over the disaster remains intense, there was a palpable sense that many people want to rescue something from this tragedy.

Serejo said donations from other museums – and the return of pieces that had been loaned elsewhere – could help that process.

“The message is we will be alive and we will keep research on its feet,” she said.

On Monday, federal prosecutors said they had requested a police investigation into the cause of the fire.

In a statement, they said they held a meeting in June 2017 with fire chiefs and the government’s Institute of Historical and National Artistic Heritage to produce fire prevention standards. “Unfortunately over a year later the federal institutions responsible have not published the standards,” prosecutors said.


Meanwhile, Serejo confirmed that two fire hydrants had run out of water as firefighters battled the fire.

Thursday, June 06, 2019

Trump and the white man's greed

 Trump and the white man's greed

Trump's trade war reminds me of the spice islands and the DUTCH


After diplomacy had failed, the Dutch demanded that the Sultan expel all foreign traders from his port and stop his own merchants from trading with those in the Moluccas who were defying the VOC-imposed monopoly. Sultan Hasanuddin was no fool and shrewdly responded: Such prohibition runs Counter to the commandment Of God, who created the world in order that all people should have the enjoyment thereof. Or do you believe that God has reserved these islands, so far away from the place of your nation. for only your trade alone? The Dutch first attacked Macassar in 1660. Their soldiers landed in the southem part of Macassar and successfully seized Fort Panakkukang but were unable to overcome the Sultan's troops and capture the rest of the city. In 1667, the VOC formed an alliance with Aru Palakka, the Ruler of Bone, in South Sulawesi, and with the aid of his Bugis warriors laid siege again to the city. Two years later the Dutch and their Bugis allies were finally able to force the surrender of Macassar, after some of the fiercest fighting they had ever experienced in the Indies. The lithograph celebrating the victory shows portraits of Dutch General Cornelis Speelman and his Bugis ally Aru Palakka above a vast scene of the battle for Macassar. The Dutch East India Company was now the richest private company the world had ever seen. It owned 150 merchant ships, 40 warships and had 30,000 employees, including an army of 15,000 soldiers. Its stranglehold on the Spice Islands was complete and all believed there was no power in the world that could break its monopoly over the trade in cloves and nutmeg.

Spice Islands

By Ian Burnett

CHOLESTEROL—AN ESSENTIAL LIPID FOR NORMAL CELL FUNCTION

CHOLESTEROL—
AN ESSENTIAL LIPID FOR NORMAL CELL FUNCTION
 As a primary care physician I have to struggle to have my patients take the statins to keep cholesterol down. It is to be noted Cholesterol  is  not the devil. it has it's beneficial uses.
Cholesterol is an essential lipid component of cellular membranes. This sterol
regulates permeability, fluidity, and bending rigidity of membranes, as well as
the activity of several membrane proteins (Maxfield and Tabas, 2005; W¨ustner,
2009). Beside this structural function, cholesterol is also the precursor molecule
for bile acid and steroid hormones synthesis. The importance of cholesterol
for cellular homeostasis is illustrated by its known contribution to development
and function of the central nervous system (CNS) and bones (Porter, 2002), to
signal transduction and sperm development, and to embryonic morphogenesis
(Bj¨orkhelm, 2002; Travis and Kopf, 2002). Various human malformation syndromes
result from a defect in cholesterol synthesis, such as Smith–Lemli–Opitz
syndrome (SLOS), desmosterolosis, Greenberg dysplasia, and Antley–Bixler
syndrome (Porter, 2002). Fatal clinical outcomes in these diseases are either a
direct consequence of a lack of cholesterol or of accumulation of a synthetic
cholesterol precursor. Its very low water solubility makes excess cholesterol
also a life-threatening condition (Tabas, 2002). This is well known from the
most frequent causes of death in the western world, cardiovascular disease and
atherosclerosis (Maxfield and Tabas, 2005). Lysosomal storage disorders such as
Niemann–Pick and Wolman diseases are either caused or accompanied by fatal
cholesterol accumulation in degradative compartments (Ikonen, 2006).

The DUTCH and Cloves

CLOVEs. This spice, so universally used, is among the earliest mentioned in any history. It derives its name from its close resemblance to a small nail: in all nations where it is spoken of, the same word is employed to designate both—cloves and nail. In France it is called clou, in Portugal, cravas, in Spain, clavas, among Latin speaking nations, clavus, each term, in the respective languages, meaning nail as well as cloves. “The clove of commerce is the product of the most beautiful, the most elegant and the most precious of all known trees.” It is a native of the true, original Moluccas. It there grows to the height of forty feet. It begins to yield the spice blooms at seven years old, and continues to bear one or two hundred years. The trunk, like the cocoanut, is perfectly straight, covered with a smooth bark of a light olive color. The branches spring out about twenty feet from the ground, horizontally, and growing very thickly, becoming shorter as they climb toward the top, where a compact mass of laure lshaped leaves crowns the highest point and forms a perfectly-shaped cone, supported by a clean, straight stem. Very many who use cloves as a spice understand that this small, nail-shaped, brownish-looking thing is the bud, and not the fruit—not even a full blossom. Before this bud is quite unfolded into the perfect flower it is gathered. It resembles, at that stage, a closely-folded convolvulus bud. At the extreme end of every twig and branch of these beautiful trees a dozen or more of these buds form a terminal cluster—first, the nail-like bud, which, if not gathered at this stage, unfolds like a fully-opened lily or convolvulus, only that from the centre shoot out innumerable stamens and anthers, filling the whole cup, like a pin-ball filled with long, large-headed pins, extending half the length of the cup or flower. Judging from the descriptions in the various cyclopaedias, especially the American, which gives the picture of a large terminal cluster, nothing can be more beautiful than a clove tree in full bloom. The stem of the clove,which we buy for spice, is the calyx, and the round, brownish head, as we see it, is the unblown corolla of these fragrant flower buds. In the Moluccas these buds are gathered in December. They are picked with as littie delay and as carefully as possible, as soon as they reach the proper stage, and speedily dried in the shade, so as to prevent, as much as can be, the exhalation or loss of the aroma. In 1521, when the Portuguese and the Spaniards first visited the Molucca Islands, they took on board their ship the first cargo of this and other spices belonging to these islands that was ever brought to Europe. These islands were then inhabited by an industrious and enterprising population, engaged almost exclusively in the cultivation of this valuable production. The clove tree was then exclusively cultivated in the Moluccas, but is now a valuable article of commerce from Sumatra, Bourbon, Mauritius and some parts of the West Indies, and will no doubt soon be common in most of the tropical regions, although that grown in its native soil still continues to be regarded as the best. In the seventeenth century the Dutch took possession of these spice islands, driving out the Portuguese, who had held them for ninety-three years, restricting the culture and preventing the free exportation of the spice. After driving out the Portuguese the Dutch established large plantations for clove culture in Amboyna, where the natives had previously introduced it before conquered by the Portuguese. “Then they, like Vandals, to secure to their own colonists a monopoly of the trade, commenced to destroy every clove tree that grew upon those islands that were their native home. Once a year they sent to Ternate, Tidor, Motir, Makian and Banshien an expedition to uproot every clove bush which migratory birds might chance to plant in their flight over the native soil of the clove ; and any native of these islands who was found to have planted a clove tree, or to have sold one ounce of these spicy buds, was put to death."

When these worse than barbarians had done this cruel work and all the lovely, magnificent forests of fragrant wood were destroyed, the fertile volcanic soil was washed away by tropical rains or scorched by the tropical sun. The land became sterile, and, having lost their trade and food, the people perished of starvation at home, or were made slaves on the plantations of Amboyna. Not only did the Dutch destroy all the clove trees of the other Molucca Islands, but also annually burned a large portion of the products of Amboyna, and in that way enhanced the value of what remained in the hands of the monopolists. This annual burning was continued until 1824.

The clove trees of Amboyna fall far short of those that were grown in their native soil. All the skill that has been brought into service to bring them back to their original beauty and magnificence has not succeeded in repairing the great injury done when the Dutch cruelly rooted them out from the Moluccas. In the region where they imperiously decided it should only be cultivated—Amboyna— the trees seldom attain to more than half their natural size, are not half as productive, and, instead of living and bearing from one to two hundred years, they seldom live over seventy years, and do not begin to bear till fifteen years old; whereas in the Moluccas it has been introduced into Bencoolen, the Straits settlements of Sumatra, at Zanzibar, in the French islands of Reunion and Cayenne, but thus far no skill or care can bring back its past glory. Doubtless there will be efforts made to replant the Moluccas with this beautiful tree, if, indeed, the attempt has not already been made. But when the Dutch rooted out and burned every tree on those islands they left the soil without any protection from the fierce heat of the tropical sun or the great rain storms of that climate; so the sun burned out all vitality from that light volcanic soil, and the floods washed a great portion of it into the sea. Now that once lovely, fertile land is like a desert, almost entirely unfruitful. To have the clove tree in perfection it must have the heat of the tropics, a mountainous declivity—the soil should be rich, loose, dry, what is known there as volcanic soil, but well-wooded, and overshadowed by the clouds and vaporous mists that rise up from such a soil.

All of the above necessities for raising the perfect clove tree and the promise of abundant fruit were combined in perfection in the Moluccas until the destroyer came and with ruthless hand uprooted all that was lovely and left these unfortunate islands desolate. One can not repress the emotion-intense indignation—when imagining what they were before invaded by cruel oppressors and then remembering what they now are.

Cloves are sometimes used medicinally, as a stimulant to digestion, but the oily cloves more frequently used to mollify or soothe the action of certain kinds of medicines. A tablespoonful of the infusion of cloves given every hour or two will often relieve nausea or excessive vomiting. The taste of offensive medicines—cod liver oil and the like—is hardly perceptible in taking immediately after chewing a few cloves. Clove fruit when ripe resembles the olive in some respects, but is not quite so large, and when fully matured is of a dark red color. It is sometimes seen in commerce in a dried state, and is then, singularly, called by the name of “Mother Cloves." It tastes and smells like the bud, but is weaker. The broken fruit stalks are also sometimes used for the same purposes as the clove, but the flower buds themselves are the most important part of the production of the clove tree for commerce, and is familiar to every one, especially to housekeepers. 



"For as long as Holland hes been Holland, there have never arrived ships as richly laden as these,' noted an anonymous obsewer of the cargoes that contained 600,000 pounds of pepper and 250,000 pounds of cloves, nutmeg,

The discovery of aequorin of jelly fish is a fascinating one

The discovery of aequorin is a fascinating one (Shimomura. 2004.2005).


This jellyfish is capable of producing flashes of blue light by a quick release of calcium(Ca2+) which interacts with the photoprotein aequorin. The blue light produced is in turn transduced to green by the now famous green fluorescent protein (GFP). Both aequorin and GFP are important tools used in biological research.

 Osamu Shimomura. (Figure 3.6) who, as a teenager, had narrowly escaped the atomic bomb when dropped on Japan at the end of World War II, was working with Frank Johnson at Friday Harbor, trying to find out how the jellyfish Aequoreu produced its light. Extracts did not seem to conform to the conventional oxygen-requiring luciferin - luciferase reaction. Frustrated arter an unsuccessful day. he threw the extracts he had prepared into the sink. Eureka — to his surprise there was a flash of blue light. beeause there was a residue of sea water there. Soon he showed it was Ca2+ in the sea water that causes the protein to flash. Na+ and Mg2+ produced no light, though other cations such as Sr2+ and La3+ can provoke aequorin and obelin to produce light.