Thursday, August 11, 2016

Those Mustard seed Ribosomes and the latest x-ray crystallography and the Nobel prize



 When  we  were in  Medical school 3 decades ago   all we  knew was  there  are  theses  small  round structures  which are on the  rough endoplasmic reticulum called  ribosomes which had  a 30 and 50 sub ubits  and  theses are involved in protein synthesis.

we have come a long way in understanding the subcellular structures in 3 decades.






Seminal Work for 2009 Nobel Prize in Chemistry Conducted at Brookhaven Lab

Venkatraman Ramakrishnan and Thomas Steitz used BNL’s National Synchrotron Light Source to produce atomic-level images of ribosomes



Biographical Information on 2009 Chemistry Nobel Prize Winners
Nature cover
Click on the image to download a high-resolution version.Ramakrishnan's high-resolution structure of 30S ribosomal subunit, based on data collected at NSLS, APS, and ESRF, published by Nature in 2000.
Venkatraman Ramakrishnan is a U.S. citizen. He was born in 1952 in Chidambaram, Tamil Nadu, India. He earned his Ph.D. in Physics in 1976 from Ohio University. He conducted research at a variety of U.S. institutions before joining Brookhaven National Laboratory’s Biology Department in 1983, earning tenure in 1990. In 1997, he left Brookhaven Lab for the University of Utah, but maintained a guest appointment and continued to use the National Synchrotron Light Source at Brookhaven until 2001, conducting research that contributed to this year’s Nobel Prize in Chemistry. He is currently a Senior Scientist and Group Leader in the Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, UK.

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