Tuesday, July 19, 2016

Drug development: Why did we volunteer

Drug development is a highly complex process that involves multiple steps of preclinical and clinical pharmacological refinement and testing. Preclinical studies include assessing drug bio availability, metabolism, and toxicity; effects on known biological targets (e.g., receptor binding); and performance in various animal models of pathology. After sufficient data are obtained in animal studies, drug testing in humans can begin. In the United States, human clinical trials are divided into four phases. Phase I involves testing multiple doses of a drug for bioavailability, pharmacokinetics, and side effects. Phase II studies are dose-finding studies in patients with a given disorder. They can be open-label or double-blind trials. Phase III generally includes pivotal double-blind trials for demonstrating efficacy and safety/tolerability. Phase IV trials, which take place after a drug has received U.S. Food and Drug Administration (FDA) approval and is on the market, are conducted to help clarify potential uses of the drug.
 We volunteered to be the normal controls for a pharmacokinetics experiment in the department  of Pharmacology when we were in the 3rd year of medical school.
this was conducted by giving us some unknown medication and then collecting our 24 hour urine  and  multiple blood samples. the study was conducted by a woman Post graduate

 Romantic vision of being a part of drug development and just the attraction of a beautiful female  giving you the attention and the closeness of her when she is drawing your blood is incentive enough to volunteer

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