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"Selective serotonin and norepinephrine inhibitors (SSNRI/SNRI) such as venlafaxine and duloxetine may also have a role in the treatment of IBS pain, although these newer agents also require careful study. Of the SSNRIs, duloxetine (Cymbalta) has been uniquely studied and marketed for both psychiatric disease and neuropathic pain. Duloxetine received FDA approval in 2004 for the treatment of major depressive disorder and diabetic neuropathy. It received FDA approval for the treatment of fibromyalgia in 2008. Given its clinical effectiveness in treating these conditions, the medication has been applied off-label for visceral hypersensitivity syndromes, including IBS. Eli-Lilly is currently sponsoring an open-label trial of duloxetine for the treatment of irritable bowel syndrome in the absence of major depressive disorder"
"Selective serotonin and norepinephrine inhibitors (SSNRI/SNRI) such as venlafaxine and duloxetine may also have a role in the treatment of IBS pain, although these newer agents also require careful study. Of the SSNRIs, duloxetine (Cymbalta) has been uniquely studied and marketed for both psychiatric disease and neuropathic pain. Duloxetine received FDA approval in 2004 for the treatment of major depressive disorder and diabetic neuropathy. It received FDA approval for the treatment of fibromyalgia in 2008. Given its clinical effectiveness in treating these conditions, the medication has been applied off-label for visceral hypersensitivity syndromes, including IBS. Eli-Lilly is currently sponsoring an open-label trial of duloxetine for the treatment of irritable bowel syndrome in the absence of major depressive disorder"
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