Thursday, November 03, 2016

DOD 's New EHR : a bunch of obsolete code a decade from now?

 Instead of coopting  opensource innovators and  modernizing a proven EHR system. ( VISTA) DOD chose to believe private sector can do better because it is "innovative"
they have awarded the  biggest contract worth about 10 Billion dollars.to cerner,accenture  leidos.


Being able to select a commercial-off-the-shelf software package and customize it as little as possible for a project this massive is the reason that DoD has given all along for not opting to use the U.S. Department of Veterans Affairs' proprietary and open source VistA EHR.

"congressional authorizers and appropriators ought to be asking the Pentagon whether it really understands what it is buying.

Military Health System CIO David Bowen
DoD Under Secretary for Acquisition, Technology and Logistics Frank Kendall.
Assistant Secretary of Defense for Health Affairs Jonathan Woodson, MD.
3 names to watch who is goi9ng to work as a consultant to cerner  in future ;-)

why do we need to learn Biostatistics

When I was in medical school 4 decades ago, the bugbear of a subject was SPM ( social and preventive medicine. only a few unfortunate souls who could't get in to lucrative  postgraduate specialities  used to end up in nonclinical specializations and  in that SPM was the last choice.

So you can expect the caliber of teachers of this most important subject  for keeping a population healthy.

Most students paid no attention to the lecturer and  were  using the time to other things.
the only time  SPM  professors had any  respect  and power was when  we had to  take the final exams.
now after spending all theses years in clinical surgery and medicine. I feel in order to make a large difference in the  health of a population preventive medicine  plays a great part.
Biostatistics lay at the heart of this speciality and  very little is taught in  medical schools in india.
and those who are teaching the rudiments  of this make the subject so boring  students either doze off in the class or walkout. i am trying to relearn biostatistics, which is fascinating to me .

  we are  increasingly neglecting  this low cost solution and  this is leading to galloping healthcare costs across the world. the emerging  economies are going to face this pretty soon if they don't wake up and   look in to this .

Two countries china and  India who comprise a major segment of the global population should put their efforts in to this and people of those countries  should stop feeling physical work is for the lower class and  being fat is a  sign of prosperity we will be able to save  Billions  ( that is with a B) of healthcare dollars.

Today’s increasingly complex surveillance systems require advanced data analysis and data management support. To adjust for missing data, account for confounders through multivariate modeling, and formally assess trends and clusters that may necessitate input from individuals with advanced training in biostatistics.

India in the limelight ?

 We  are so proud of India's emerging economy. We want to be in the same playing field as the  big boys ,look at NSG, BRICS,

But are we really in that field or  still  stuck in that  old and  forgotten  field of developing  countries .

when looking at  the rampant  infectious disease epidemics  resurgence in Urban and  rural India  I doubt  we  are in the  same  field as the big boys.
let us  rebuild the  public health infrastructure  which has fallen in to disuse due to  neglect corruption and  sheer  apathy and  laziness of us Indians
All countries in the WHO South-East Asia region introduced measles vaccine in their immunization programs during the 1980s. Subsequent to the global measles elimination initiative, the reported immunization coverage increased in the region from 1999 to 2005 http://jidoxfordjournals.org/content/204/suppl_1/S421.full#ref-3

 As a consequence, the estimated number of cases decreased by 27% from1999 to 2005 
Four countries in the region have already initiated surveillance for measles elimination. However, India, Bangladesh, Myanmar, Timor Leste, and Nepal still face challenges in measles control. In 2005, in these countries, the reported coverage ranged between 48%–81% and the annual incidence was .15–2.7 cases per million people, respectively

Human healthcare need to collaborations with entomologists, veterinarians, and wildlife oversight agencies [

Surveillance collaborations with partners outside traditional human public health systems 


As illustrated by the broad variety of infectious disease surveillance systems, diverse sources of information can be utilized. The development of these systems relies upon new collaborations between human public health agencies and nontraditional partners. For example, domestic and wildlife animal health agencies have traditionally acted as separate entities apart from human health agencies. However, the increasing recognition of the importance of zoonotic diseases to human health has encouraged innovative collaborations. When West Nile virus emerged in the US, public health officials who customarily focused only on human diseases began forging collaborations with entomologists, veterinarians, and wildlife oversight agencies [42]. Human health agencies often do not have these diversely skilled personnel, but instead depend upon common goals and national agendas to facilitate collaborations.

Use of computer algorithms to conduct surveillance

Use of computer algorithms to conduct surveillance 


A few surveillance systems have been developed that employ computer algorithms to screen electronic data sources for disease cases and apply automated statistical methods to assess data trends and changes in case activity. For example, a component of the Infectious Diseases Surveillance and Information System (ISIS) in the Netherlands runs automated algorithms on electronically-transmitted laboratory data to identify selected cases of public health interest (e.g., new positive Neisseria gonorrhea test results). Automated time-series analyses process these and other surveillance data to detect variations from expected rates; statistically significant changes automatically generate and distribute alerts (see Chapter 22). Syndromic surveillance systems use automated data extraction and analyses methods to detect aberrations from expected levels of various syndromes

Although these systems exhibit the powerful capacity of technologies to automatically process enormous quantities of data, humans must still verify, investigate, and prioritize these reports. Research is needed to refine these automated data processing systems and capitalize on their strengths.

What happens when you fall asleep on the steering wheel?

What happens when you fall asleep on the steering wheel?
we will start back from square one  in a game of snakes and ladders.

 Little information is available about measles epidemiology in India. Reliable surveillance data are missing and few outbreaks are investigated

"In disease eradication programs, robust surveillance systems are necessary to detect every case. However, with low levels of disease, it is hard to convince decision makers to allocate sufficient resources for surveillance and a risk of undetected relapse remains. As a result of an ambitious plan to eradicate malaria in the mid-1950s, some countries (e.g., India) had sharp reductions in the number of cases followed by, after efforts ceased, increases to substantial levels"


The desire of societies to control the spread of highly contagious and virulent infectious pathogens (e.g., pandemic strains of influenza virus) may allow acceptance of quarantine by public health authorities even at the expense of individual liberty. However, without surveillance data, public health officials will have difficulties designing rational isolation and quarantine strategies and can expect to encounter legal obstacles and public disapproval.

Merely collecting disease data for surveillance has little impact. 

However, successful surveillance programs also analyze and disseminate data to inform prevention and control activities.

Control emergence of antimicrobial-resistant organisms in domesticated animals Widespread use of antimicrobial agents as growth promoters in animal husbandry is associated with increased resistance to antibiotics in bacteria isolated from animals and humans [19]. Surveillance for antimicrobial-resistant organisms in food animals is important to inform policies regarding use of antimicrobials outside human medicine. For example, the Danish Integrated Antimicrobial Resistance Monitoring and Research Programme (DANMAP) was established in 1995 to monitor antimicrobial resistance in bacteria from livestock, food, and humans, and to monitor use of antimicrobial agents [20]. Due to demonstration of rising antimicrobial resistance among bacteria isolated from food animals, Denmark banned use of certain antimicrobial agents as growth promoters in the 1990s (e.g., avoparcin, a glycopeptide similar to vancomycin, in 1995)


Detect and respond to emerging infections Surveillance is useful for detecting and controlling new or reemerging pathogens. The recent outbreak of SARS illustrates the role of surveillance in guiding response to an emerging global public health threat. First reported in Guangdong Province, China, in 2003, SARS resulted in 8098 probable cases with 774 deaths reported in 29 countries. Surveillance played a critical role in assessing the spread of the SARS epidemic and guiding quarantine recommendations and other control measures 

Despite being legally mandated, diseases are grossly underreported [28]. There are essentially no penalties for failing to report cases of disease. Health-care providers and other reporters are often unaware of which diseases to report, they may not believe in the utility of surveillance, and the logistics of reporting cases can become unmanageable for busy clinicians. Creative means to motivate and support disease reporters is essential, but often overlooked.


a classic example of falling asleep on the steering wheel?

chikungunya was made a mandatory notifiable condition in mainland France and the overseas departments in the Caribbean, but not in the department La Reunion in the Indian Ocean, where a ´ massive epidemic involving over 100,000 persons in 2006 overwhelmed the disease reporting structure

However, infectious pathogens do not respect country borders, and therefore some disease outbreaks are not solely the concern of the “index” country—intensified global public health response may become essential.
( this was made so clear to me  when I was  searching  for measles in Hyderabad ( without putting telangana in the search box)  I came  across  a number  of reports of  measles deaths  in Hyderabad ,Pakistan

Official assessments from WHO, as an internationally prominent and neutral public health authority, can avoid unnecessary, uncoordinated interference with international traffic and trade that has previously made some countries reluctant to report significant events.

Many surveillance strategies involve collaborations with laboratories for sharing of data and isolates. For example, utilizing advancing information technologies, public health organizations have worked with clinical laboratories to enable electronic, automated transfer of information on reportable diseases to public health agencies ( some thing like self driven cars!)
(Infectious Diseases Surveillance Information System (ISIS) in the Netherlands: development and implementation).

 A different benign ISIS


. It is also true that no surveillance system should be entirely “passive,” even from the point of view of the public health agency, as regular communication and feedback to healthcare providers are necessary.


The Foodborne Disease Surveillance Network (FoodNET) established by the US CDC in collaboration with the US Department of Agriculture and the US Food and Drug Administration, and participating US Emerging Infection Program sites, is an active, laboratory-based surveillance program for foodborne pathogens 
. Typically, only a small fraction of foodborne illnesses are reported to public health authorities, and often they lack accurate epidemiologic information (e.g., specific attributed causes, outcomes).

In France, a network of primary care physicians report information, at weekly intervals, on a selected group of health events that are relatively common in general practice: influenza-like illness, acute gastroenteritis, measles, mumps, chicken pox, male urethritis, hepatitis A, B, and C. Data are extrapolated to regional and national levels. The system detects and describes the occurrence and progression of regional and national outbreaks (available at: http://rhone.b3e.jussiue.fr/senti).


zoonotic diseases cannot be adequately understood and controlled by only monitoring the disease in human populations. Brucellosis control in the US has been successful because of the focus on animal health as a way to protect human health—comprehensive animal testing, vaccination of breeding animals, and depopulation of affected herds ( a politically correct way of saying  kill the animals ) ( what will Maneka Gandhi and all the  GoRAKSHAKS say to this ?)

The identification of the fungus Cryptococcus gattii in British Columbia, Canada, illustrates the use of surveillance to detect and define an emerging pathogen intrinsically linked to the environment. This fungus was previously known only in tropical and subtropical climates, but the organism emerged around 1999 in Vancouver Island as a pathogen in humans and domestic and wild animals. Environmental sampling has identified the fungus on trees, in soil, in air samples, and in water

healthcare facilities in the US assign diagnosis codes (e.g., International Classification of Diseases, Tenth Revision (ICD-10)) to clinical care encounters—this is a potential data source for surveillance for a range of diseases ( but  most of  the  codes are  not utilized properly due to a very cumbersome access and also lack of lab testing  mainly in poorly funded community clinics  where theses cases are more likely to occur)


Monitoring of drug utilization and drug sales may be an indirect measure of disease activity. Pharmaceutical databases have been explored for a variety of syndromic surveillance systems. At the US CDC, where a supply of “orphan” drugs are housed for treatment of rare diseases, increased requests for pentamidine in the 1980s led to an investigation of a cluster of Pneumocystis pneumonia which, in turn, led to the first detection of AIDS in the world



Use of media reports for disease surveillance 


The availability and speed of information transmission over the Internet have allowed development of innovative electronic media-based surveillance systems. For example, the Global Public Health Intelligence Network (GPHIN) gathers, in seven languages on a real-time, 24/7 basis, electronic media reports of occurrence of diseases. Although the electronically gathered information requires further verification, GPHIN is used extensively as an early source of outbreak information by Health Canada, WHO, the US CDC, and others ( should they not add more languages? can they  use automatic translation of various  other languages in to the  7 languages  to improve  this ?may be they can use the help of Google to translate!

Measles in the present day and age “What happens to public health in the absence of surveillance?”

Measles can be prevented with the MMR (measles, mumps, and rubella) vaccine.
 One dose of MMR vaccine is about 93% effective at preventing measles if exposed to the virus,
 and two doses are about 97% effective.
 In the United States, widespread use of measles vaccine has led to a greater than 99% reduction in measles cases compared with the pre-vaccine era.
 Since 2000, when measles was declared eliminated from the U.S., the annual number of people reported to have measles ranged from a low of 37 people in 2004 to a high of 668 people in 2014. Most of these originated outside the country or were linked to a case that originated outside the country.
what was the incidence in India  during the same time?????
Measles is still common in other countries. The virus is highly contagious and can spread rapidly in areas where people are not vaccinated. Worldwide, an estimated 20 million people get measles and 146,000 people die from the disease each year—that equals about 400 deaths every day or about 17 deaths every hour.

Measles surveillance emphasizes (1) regular reporting of cases, (2) investigating outbreaks, and (3) monitoring vaccination coverage. Investigations of outbreaks provide information that allows prevention of future ones. This includes identification of high-risk groups, description of changes in measles epidemiology, and detection of weaknesses in routine immunization. In addition, outbreak investigation is followed by administration to case patients of vitamin A, an intervention that is effective in reducing the case fatality [2]. In 2005, WHO considered that from 1999 through 2005, measles deaths had been reduced by 60% globally [3]. However, India accounted for a substantial part of the remaining burden.

Inadequate surveillance and consequent “blindness” to the health status of the population has contributed to the uncontrolled global spread of the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), one of the worst pandemics in human history. Without accurate surveillance data to understand the true health status of their populations and to guide the use of limited public health resources, leaders can be grossly misinformed and, as in the case of HIV/AIDS, lose opportunities for early prevention and control before the virus becomes entrenched.

VIP tantrum puts air safety at risk

VIP tantrum puts air safety at risk

- PM seeks report, deputy CM unapologetic after flight from Leh is delayed

Artistes perform at the Hemis festival, held every year at the Hemis Gompa monastery in Ladakh, in the last week of June. Nirmal Singh was in Leh to attend another annual festival, the Sindhu Darshan. (PTI) 
New Delhi, July 2: The Narendra Modi government was today rushing to shield itself from middle-class ire after a minister used his VIP status to delay flights in a manner that not only showed arrogance but also raised questions on flight safety.
The Prime Minister sought a report from the Union civil aviation ministry this evening after minister of state for home, Kiren Rijiju, and the deputy chief minister of the Jammu and Kashmir government were recorded having a tiff with passengers and the crew of an Air India flight from Leh on June 24 that was delayed to accommodate them.
The VIPs were taken onboard the flight that was delayed while an Indian diplomat travelling with his family was not allowed to enter the aircraft that was on a Delhi-Leh-Srinagar-Leh-Delhi flight.
Landings and take-offs from Leh, at a height of more than 10,000 feet, are dictated by the weather and the availability of oxygen in the air.

Kiren Rijiju
As the temperature increases, the air gets warmer and rises, leading to lower air pressure and low-density air near the ground. This means there is relatively less oxygen per unit volume to be used by the aircraft engines for combustion.
As such, air traffic control has warned against take-offs of civilian flights from Leh after 10.35 in the morning by when the sun is out and the availability of oxygen for the intakes of large aircraft is doubtful.
Attempting to take off after the deadline puts the lives of the passengers and crew at risk. However, depending on factors such as cloud cover, the take-off time can be stretched a bit if the pilot concludes that it is risk-free. The particular flight was originally scheduled to take off at 11.15am
Junior home minister Rijiju, who also apologised in interviews for inconveniencing passengers, denied that he was the cause of the delay.
But the report of the Indian Air Force, which is in charge of the Leh airfield, shows the aircraft's departure was delayed refers to the minister.
"On 24 Jun 15, AI-446 was to depart at 1020h as per revised schedule (scheduled ETD - 1115h). The aircraft landed in time from Delhi and passengers started boarding for the return flight to Delhi. In the meanwhile, 21 Wg ATC was contacted by the Airport Director requesting a delay in departure to accommodate a VIP (MoS MHA). The flight eventually departed at 1112h," said the report.
The 21 Wing Air Traffic Control monitors landings, take-offs and overflights at Leh. MoS MHA is short for minister of state, ministry of home affairs.
The report said that three passengers, G.V. Srinivas, G.V. Neelam and G.V. Dhruv Aryan were not allowed to board the aircraft as they came late. Srinivas, a joint secretary with the external affairs ministry, and his family were on a personal visit to Leh where a relative who is with the air force, Squadron Leader Ajay Gupta, is stationed.
The IAF found from the airport authorities that the captain of the Air India flight 446, R. Saharan, "came out of the aircraft prior to the arrival of the VIP and interceded on behalf of passengers and also told them that the delay is not due to any fault of Air India".
In a separate complaint against the pilot to the Union civil aviation minister, Ashok Gajapati Raju, Nirmal Singh wrote: "On the same pattern of rural bus service, I experienced that pilot dictated the time of departure and arrival and also the passengers to board the plane (sic)".
Singh failed to understand that it is indeed the responsibility of the pilot - the captain - to decide on when to shut the doors and take off. The plane was already nearly 40 minutes past the deadline for take-offs from the high-altitude airfield.

Nirmal Singh
Home ministry sources said Rijiju was scheduled to take a BSF helicopter on June 24 from Leh to Jammu and from there a flight to Delhi.
"But because of bad weather the BSF helicopter could not take off from Jammu and the Leh administration was asked to book a ticket in the last flight from Leh to Delhi. This is normal routine arrangement in bad weather for this kind of situations for VIPs protocol," said a senior official attached to Rijiju office in North Block.
He sought to explain that the minister was not aware of "off-loading" of the three passengers.
"The three passengers were not allowed to board and it was never informed to the minister. This step would have never been appreciated if brought to the notice on the same day," the official said.
Another official in North Block said the three passengers were not allowed to board only to accommodate the VIP passenger Rijiju who was accompanied by Jammu and Kashmir deputy chief minister Nirmal Singh.
"By the time Rijiju's car reached the tarmac, the pilot had already closed the aircraft's door. But Air India received a request for a delay in departure to accommodate the VIP passengers," the ministry official said.
"The pilot came rushing down from the aircraft ladder and told Rijiju that it was not appreciable to delay the departure of the aircraft. This angered Singh who got into a verbal duel with the pilot and threatened to teach him a lesson," the official said.
After nearly three minutes of argument the pilot relented and allowed them in.
"But the heated argument between the pilot and Singh started again inside the aircraft once the door was closed. It was then some passengers came to the rescue of the pilot and protested against the VIP culture and also recorded the argument on their mobile cameras," the official said.
Sources in the ministry said the pilot was "stern" in his approach irrespective of the presence of a VIP and played by the rulebook.
"In fact, the fault lies with Singh who tried to browbeat him, flaunting his political status. But still that did not deter the pilot who stuck to his ground and tried to convince them that what they did was simply wrong and concerns the security of so many passengers," another official said.
Union civil aviation minister Ashok Gajapati Raju said he was sorry that passengers were inconvenienced.
Raju said the "indefensible" incidents should never have happened. "Whatever has happened should not have happened... I need to get to the truth," Raju said.
Junior home minister Rijiju told PTI: "Air India, being a government PSU, we as ministers, have the moral responsibility if any passenger has undergone any inconvenience. We must say sorry to them on behalf of the government and ensure that such incidents do not occur in future."
Singh, the deputy chief minister, said he was in Leh to attend the Sindhu Darshan festival and had booked the return tickets the same day by an Air India flight "which was to depart at 11.20 am".
"Around 9.53am, when I was performing rituals on the banks of the Sindhu, I received a message from some official that the Air India flight has reached early and is ready to depart," he said in a complaint to Raju.
Singh said the ceremony was concluded early at his request and he reached the airport at 10.48 am. "I collected my boarding pass where in the time for boarding was written as 10.40am but to my surprise, the pilot had closed the doors of plane.
"The order of the pilot to close the door was wrong so I rushed to the tarmac. Pilot Mr Saran instead of apologising for his wrong actions rushed down from the ladder and created a dramatic situation and rudely behaved," Singh said in his complaint.

Best way to spread Infectious diseases !

 Today morning  I was having a telephone talk with an old friend of mine in Hyderabad Telangana  India ( I will explain why I am giving the specific geographic location).
Infectious pathogens do not respect country borders, and therefore some disease outbreaks are not solely the concern of the “index” country—intensified global public health response may become essential.
( this was made so clear to me  when I was  searching  for measles in Hyderabad ( without putting telangana in the search box)  I came  across  a number  of reports of  measles deaths  in Hyderabad ,Pakistan
My daughter and  2 grand kids are on an extended vacation in India
 3days ago I got a call from her saying my grandson has measles and that they may have to postpone their return to USA.

I mentioned this to my friend who said he was not aware of any increased measles incidence in the city.When I told him to look up the Deccan Chronicle article published yesterday,his response was  "DC is an opposition news paper they will print anything to defame the Government".
I was in a hurry to reach my work so I did not have  a longer conversation.
So when I had  some  free time at work as one of the  patients cancelled  I started with this post .while searching  I came across another  article  from  Deccan chronicle.
I have theses questions.I would like some answers.

1) If isolation  of  people with infections is a good idea  isn't congregations  like this are the best way to spread those  infectious diseases?
2) How come  we still have  only the one fever/ID hospital  for the state  which was built by a former ruler of Hyderabad  state. What was being done about this all theses  60 + years  of independent  Indian rule?
3) What happened  to preventive medicine ? why do we have  so many diarrhea cases  are we not teaching  our children  the basics of  cleanliness. when I was in school  55 years ago  we had  a lesson on  keeping  one clean  how to keep surroundigs clean  and  how to avoid contaminating  ground water  etc.
Now we talk of high technology and  indian space program. What has happened to clean drinking water and  pollution  free air  and  effective vaccinations.
4) How good is the coldchain  mangement  in India when  vaccinations  are given on a massive scale?
5)  As my grandson was vaccinated  in USA I could possibly assume proper cold chain management  so  what is the  effectiveness of MMR?
here is an article  on  MUMPS vaccine effectiveness

Evaluation of Mumps Vaccine Effectiveness by outbreak investigation in one kindergarten in Ulsan city, 2006.  
http://www.koreamed.org/SearchBasic.php?RID=0073KJE/2008.30.1.110&DT=1

"






(2 Aug) Hyderabad: More than 1,500 out-patients were treated at Fever Hospital on Monday complaining about diarrhoea, viral fevers, typhoid fever, diphtheria and mumps. Of these 22 cases were of dog bites including largely children from the age-group of 5 years to 10 years. According to doctors most of the dog bite cases were from Ranga Reddy, Mahbubnagar and Nalgonda districts surrounding the city. Fever Hospital superintendent Dr K. Shanker said, "Due to the rainy season we are seeing 500 to 700 patients every day in the out-patient department. On Monday, the number was the highest. Earlier we have had 1,000 patients in the out-patient department."Of these patients, admissions were 15 as they required hospitalisation. A senior doctor said, "Six of the patients had severe gastro-intestinal problems, two were suffering from typhoid fever, two from diphtheria and one from mumps. The others came in a critical stage and their diagnostic tests are going to confirm the disease later." The cases of diarrhoea were from L.B. Nagar, Rajendranagar and Musheerabad while the typhoid fever is from Nalgonda district and diphtheria and mumps are from surrounding Ranga Reddy areas. In July, there were 30 cases of diphtheria, 15 cases of dengue, 20 cases of dog bites, ( once again my favourite topic) 10 cases of mums and measles and also nine cases of cholera reported in the hospital.



Wednesday, November 02, 2016