A study from Children's Hospital of Pittsburg and Pittsburgh Medical Center, has shown that type 1 diabetes can be reversed in a mouse model. The scientists extracted the mouse's dendritic cells from the blood and enhanced them with specific molecule blockers. They then reinjected them into the mouse. This procedure stopped the process that kills beta cells, by blocking the T cells which attack them.
A series of injections over the course of several weeks interrupted the T cell attack on the beta cells of the pancreas and allowed the beta cells to regenerate. This resulted in the pancreas of the mice producing insulin again.
Now, the researchers at the Children's Hospital are moving on to human trials. Phase I of the trials was set to start this this past March, to determine the safety of the procedure. Scientists are hopeful that the trials will be successful.
the details are available here
href="http://www.clinicaltrials.gov/ct2/show/NCT00445913?term=type+1+diabetes+dendritic+cells+AND+pittsburgh&rank=1">http://www.clinicaltrials.gov/ct2/show/NCT00445913?term=type+1+diabetes+dendritic+cells+AND+pittsburgh&rank=1
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