Fat cells. derived stem cells further treatment of juvenile diabetes

About one year ago,

I received and e-mail from a father, asking about whether he should have a son take this treatment, which is being offered by a doctor from Gujarat.

that time. I had cautioned him to tread carefully and wait for and year or two before jumping. The gun.

although I had checked up the credentials of Dr.H.L.Trivedi.

his current and chills were impeccable,

but the lack of animal experimentation, and also lack of any published papers on this approach.

made me suspicious of the claims.

but I was waiting for a Publication in a peer reviewed Journal.

today while searching I came across the above article.

I am surprised that this has not caused a widespread sensation and the news media.

I have ordered for the article, once I have read article I will post my opinion.

I will also post a common man's explanation of what exactly was done, and what were the results.

and what we can expect in future.

the abstract of the article given below.

http://www.ncbi.nlm.nih.gov/pubmed/18555133

: Transplant Proc. 2008 May;40(4):1135-9.
Links
Human adipose tissue-derived mesenchymal stem cells combined with hematopoietic stem cell transplantation synthesize insulin.
Trivedi HL, Vanikar AV, Thakker U, Firoze A, Dave SD, Patel CN, Patel JV, Bhargava AB, Shankar V.
Department of Nephrology and Transplantation Medicine, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Centre, Dr. H.L. Trivedi Institute of Transplantation Sciences, Ahmedabad, Anand, India. ikdrcadl@sancharnet.in
BACKGROUND: Type 1 diabetes mellitus (DM) is an autoimmune disorder with disturbed glucose/insulin metabolism, which has no medical treatment other than life-long insulin therapy, despite which 30% of subjects develop organ failure. Herein we have reported the use of human adipose-tissue-derived, insulin-making mesenchymal stem cells (h-AD-MSC) transfused with unfractionated cultured bone marrow (CBM) in 5 insulinopenic DM patients. PATIENTS AND METHODS: Five (M:F, 2:3) insulinopenic DM patients of 0.6 to 10 years' duration, ages 14 to 28 years under treatment insulin (Human with 14-70 U/d) showed postprandial blood sugars between 156 to 470 mg%, glycosylated hemoglobin 6.8% to 9.9% and c-peptide levels of 0.02 to 0.2 ng/mL. They underwent intraportal administration of xenogeneic-free h-AD-MSC (mean dose = 1.5 mL; cell counts, 2.1 x 10(3)/muL). The CD45-/90+/73(+) cells (29.8/16.8%) showed c-peptide levels of 3.08 ng/mL, insulin level of 1578 micro IU/mL. The aliquot was supplemented with CBM (mean dose 94 mL with cell counts: 18.7 x 10(3)/microL) containing CD45-/34+ elements of 0.93%. The Institutional Review Board approved the study protocol and consent forms. RESULTS: All patients were successfully infused CBM plus h-AD-MSC without any untoward effects and showed 30% to 50% decreased insulin requirements with 4- to 26-fold increased serum c-peptide levels, with a mean follow-up of 2.9 months. CONCLUSION: This report describes safe and effective treatment of insulinopenic diabetics using insulin-producing h-AD-MSC plus CBM without xenogeneic materials.
PMID: 18555133 [PubMed - indexed for MEDLINE]

some interesting articles on Dr. Trivedi realy fascinating.

http://goggly.blogspot.com/2006/02/real-life-hero-of-swades.html

{ the original email which alerted me to dr. Trivedis experiments .

prakashthakrar@gmail.com
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DR H L TRIVEDI OF AHMEDABAD, GUJARAT, INDIA IS ON WAY TO CURE TYPE 1 / JUVENILE DIABETES ?
DR H L TRIVEDI OF AHMEDABAD, GUJARAT, INDIA IS ON WAY TO CURE TYPE 1 /JUVENILE DIABETES ?Here in India, ETV Gujarati telecasted interview of Dr H L Trivedi on15th August 2007.Click the link to see the news in detail:-http://www.medicaldaily.net/link.asp...Gujarat%20docsOn 17th, I contact his hospital TELEPHONICALLY & inquired about theavailability of the treatment to Diabetics; especially about my 16 yrJuvenile Diabetic only Son*. A lady named Nalinibahen, replied on hisbehalf over the telephone that I may go to there in Ahmedabad duringany Monday to Friday with prior appoint. On inquiry, She gotconfirmation that blood group of my son & of mine is equal. She toldme about the procedure that on arrival, they, through minor surgery,collect a piece of fat from my stomack & let us leave the hospital forabout 15 days. During these period, they will cultivate stem cellsfrom it. When stem cells r ready from the fat, they will call us fortreatment of my Juvenile/Type 1 Diabetic Son. She informed me overTELEPHONE that they will transplant the stem cell into lever of thepatient. After that, the patient has to let admitted for about 1month. On inquiry, she told me their charges, Rs. 1 Lac.WHAT DO U THINK ABOUT THIS NEWS WHEN SUCH TYPE OF RESEARCES ARECONTINEOUSLY GOING ON ALL OVER GLOBE ?HONEST OPINION PLEASE...!!!Prakash Thakrar, India}