Pharmacotherapy for obesity 2 - pharmacological agents in current use & under development

Pharmacotherapy for obesity 2 - pharmacological agents in current use & under developmentProf. 



Joe Proietto – University of Melbourne, Australia






 Nature combines nine gut and pancreatic hormones and several 
nutrients to suppress hunger so, it is better to use multiple drugs 
at their lowest doses to control hunger rather than just one drug 

at a high dose 

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Navigable Slide Index

1. Introduction
2. Pharmacotherapy for obesity
3. Phentermine
4. Phentermine: methods
5. Phentermine: results
6. Weight loss with phentermine
7. Phentermine: conclusions
8. Topiramate
9. Topiramate: introduction
10. Topiramate: dose escalation
11. Topiramate: study randomization protocol
12. Topiramate: results
13. Topiramate: complications
14. Phentermine plus topiramate
15. Phentermine + topiramate: randomization protocol
16. Phentermine + topiramate: results
17. Phentermine + topiramate: side effects
18. First Australian phentermine + topiramate trial (1)
19. First Australian phentermine + topiramate trial (2)
20. Phentermine + topiramate: results (Australia)
21. Phentermine + topiramate: conclusion (Australia)
22. Orlistat
23. Orlistat: introduction
24. Orlistat: methods
25. Orlistat: results (1)
26. Orlistat: complications
27. Orlistat: results (2)
28. Liraglutide
29. Liraglutide: randomization protocol
30. Liraglutide: results
31. Liraglutide: side effects
32. Lorcaserin
33. Lorcaserin: aim
34. Lorcaserin: patients
35. Lorcaserin: intervention
36. Lorcaserin: main outcome measures
37. Lorcaserin: results (1)
38. Lorcaserin: results (2)
39. Lorcaserin: side effects
40. Lorcaserin: conclusion
41. Naltrexone plus bupropion
42. Naltrexone plus bupropion: introduction
43. Naltrexone plus bupropion: methods (1)
44. Naltrexone plus bupropion: methods (2)
45. Naltrexone plus bupropion: results
46. Naltrexone plus bupropion: side effects
47. Medications under investigation
48. Semaglutide
49. Semaglutide: methods
50. Semaglutide: results (1)
51. Semaglutide: results (2)
52. Pramlintide (amylin)
53. Pramlintide: aim
54. Pramlintide: methods
55. Pramlintide: results
56. Pramlintide: side effects
57. Pramlintide: conclusions
58. Metreleptin (leptin)
59. Metreleptin: aim
60. Metreleptin: methods
61. Metreleptin: results (1)
62. Metreleptin: results (2)
63. Pramlintide plus metreleptin
64. Pramlintide plus metreleptin: aim
65. Pramlintide plus metreleptin: methods
66. Pramlintide plus metreleptin: results
67. Beloranib
68. Beloranib: aim
69. Beloranib: methods
70. Beloranib: results
71. Beloranib: side effects
72. Beloranib: Post Script
73. Combination of hormones
74. Combination of hormones: aim
75. Combination of hormones: methods
76. Combination of hormones: results (1)
77. Combination of hormones: results (2)
78. Major points about weight loss medications