AIDS
Ami
ATP
Aus
BAGE
BHRFI
BMLFI
BMRFI
BMT
BZLFI
c
CDK4
CDR
c.fes
CKS
CLIP
c.myc
COOH
c•pim
CREC
CSA.19
alanine
acquired immune deficiency syndrome
American Indian
antigen presenting cell
ankylosing spondylitis
adenosine triphosphate
Ausualian Aboriginal
beta-2 microglohulin
tumour antigen
Epstein-Barr virus lytic cycle antigen
Black
Epstein-Barr virus lytic cycle antigen
Epstein-Barr virus lytic cycle antigen
bone marrow transplantation
Epstein-Barr virus lytic cycle antigen
cysteine
congenital adrenal hyperplasia
cluster of differentiation
cell division control protein
cycline dependent kinase
complementarity determining region
proto-oncogene
cycline dependent kinase regulatory subunit
class II-associated invariant chain peptide
proto.oncogene
carboxy
proto-oncogene
cross-reacting group Of antigens
60S ribosomal protein LIOA
CDR
c-fes
c.myc
COOH
c•pim
CREC,
CSA-19
DDB'
DEK
Der p
EBNA
EBV
EMBL
ERP
ESAT
EST
complementarity determining region
to-oncogene
cycline dependent kinase regulatory subunit
class II-associated invariant chain peptide
carboxy
proto-oncogene
cross-reacting group of antigens
60S ribosomal protein L IOA
cytotoxic {or cytolytic' T lymphocyte
aspartic acid
DN A Bank Of 'apan
transcriptional regulatory protein
Derma tophagoides pteronyssinus
glutamic acid
Epstein •Barr virus nuclear antigen
Epstein-Barr virus
ethnic group
European Molecular Biology Laboratory
endoplasmic reticulum
endoplasmic reticulum resident protein
early secreted antigenic target 6 kDa protein
expressed sequence tag
Ami
ATP
Aus
BAGE
BHRFI
BMLFI
BMRFI
BMT
BZLFI
c
CDK4
CDR
c.fes
CKS
CLIP
c.myc
COOH
c•pim
CREC
CSA.19
alanine
acquired immune deficiency syndrome
American Indian
antigen presenting cell
ankylosing spondylitis
adenosine triphosphate
Ausualian Aboriginal
beta-2 microglohulin
tumour antigen
Epstein-Barr virus lytic cycle antigen
Black
Epstein-Barr virus lytic cycle antigen
Epstein-Barr virus lytic cycle antigen
bone marrow transplantation
Epstein-Barr virus lytic cycle antigen
cysteine
congenital adrenal hyperplasia
cluster of differentiation
cell division control protein
cycline dependent kinase
complementarity determining region
proto-oncogene
cycline dependent kinase regulatory subunit
class II-associated invariant chain peptide
proto.oncogene
carboxy
proto-oncogene
cross-reacting group Of antigens
60S ribosomal protein LIOA
CDR
c-fes
c.myc
COOH
c•pim
CREC,
CSA-19
DDB'
DEK
Der p
EBNA
EBV
EMBL
ERP
ESAT
EST
complementarity determining region
to-oncogene
cycline dependent kinase regulatory subunit
class II-associated invariant chain peptide
carboxy
proto-oncogene
cross-reacting group of antigens
60S ribosomal protein L IOA
cytotoxic {or cytolytic' T lymphocyte
aspartic acid
DN A Bank Of 'apan
transcriptional regulatory protein
Derma tophagoides pteronyssinus
glutamic acid
Epstein •Barr virus nuclear antigen
Epstein-Barr virus
ethnic group
European Molecular Biology Laboratory
endoplasmic reticulum
endoplasmic reticulum resident protein
early secreted antigenic target 6 kDa protein
expressed sequence tag
Ets- I
FcR
C,
GAD
GAGE
GBLP
C.IcNac
C,MCSF
GSDB
c,VHD
C,VL
HBV
HCMV
HCV
HER.2/neu
His
HIV
HPLC
HPV
HSI
HSC
HSP
transcription factor
phenylalanine
ribosomal protein S30 fused to a ubiquitin-like
Fe receptor
glycme
glutamic acid &carbOxylaSc
tumour antigen
guanine nucleotide binding protein b suburut•llke pre
granulocyte / macrophage colony stimulating factot
glycoprote.n
melanoma anugen 'same as "melt
Genome Seq ucnCC Database
gait •versus•host disease
graft •versus •leukemia
hust idine
histcxompatibility antigen 2 (of mice'
hepatitis B virus
human cytomegalovirus
hepatitis C virus
proto-oncogene
Hispanic
human immunodeficiency virus
human leucocyte antigen
high performance liquid chromatography
human virus
haematopoetic lineage cell specific protein
heat protein constitutive
heat protein
HSC
HSP
Hsrn
HSV'
HTLV
ICAM
IDDM
IFN
IL
Int-6
rrAM
ITIM
kDa
KIR
heat shock protein constitutive
heat shock protein
human seminal
herpes simplex Virus
human T lymphotrophic Virus
isoleucine
intercellular adhesion molecule
insuhn•dependent diabetes mellitis
isoelectric focusing
interferon
immunoglobulin
invariant cham
interleukin
immunoglobulin.like transcript
translation imtiation factor subunit
gamma interferon-inducible protein
immuno•tyrosine activating motif
immuno-tyrosine inhibitory motif
lysine
kilobase
kilo-dalton
killer.cell immunoglobulin.like receptor
LOL
LGL
LIR
Lmp 2/7
Lmp• 112
LOI p
LRC
M.
MAGE
MART.I/
MET
MG
MHC
MIC
Mix
MLC
MUWI
NKC
NMDP
leucine
low density lipoprotein
large granular lymphocyte
leukocyte immunoglobulin-like receptor
low molecular mass polypeptides 2/7
Epstein-Barr virus latent membrane protein 1/2
lx»liurn perenne
lymphocyte receptor complex
methiomne
Mycobacterium sp.
melanoma anugen
melanA / melanoma antigen
megabase
proto-oncogene
myasthenia gravis
major histocompaubility complex
MHC class I •related chain
MHC class II compartment
mixed race
mixed lymphocyte culture
multiple sclerosis
tumour antigen
asparagine
not available
not determined
natural killer
natural killer complex
United States National Marrow Donor Program
NKC
N',MDP
Pac
PCR
PGK
PLT
pmel
PRAME
RAGE
RBAP.2
RFLP
S
not determined
natural killer
natural killer complex
Umted States National Marrow Donor Program
nonstructural protein
Oriental
prohne
Plasmodium sp.
Pacific Islander
rolymcrase chain reaction
phosphoglycerate kinase
primed lymphocyte typing
melanoma antigen
'Kilymerasc
tumour antigen
glutamine
arginine
rheumatoid arthritis
tumour ant igen
proto-oncogene
retinoblastoma-associated protein
restriction fragment length polymorphism
sequence-based typing
SHP
SLE
SMCY
ssop
ssp
SSR
ST ARP
TAP
TCR
TIS
TRAP
TRP
VLA
SH2 domain containing protein
systemic lupus erythematosis
male.specific transplantation antigen
sequence.specific oligonucleotide probe
sequence-specific primer
signal sequence receptor
sporozoite threonine and asparagine rich protein
threonine
transporter associated with antigen processing
HTLV•I trans activator
receptor
early response factor induced by growth and tumour promoters
thrombospondin related anonymous protein
melanoma antigen
unknown amino acid
valine
adhesion receptor
tryptophan
isoleucine or leucine
About a hundred years ago, biologists interested in cancer began to study the tumours that sometimes spontaneously arise in domesticated mice. Because each tumour died with the mouse in which it arose, investigators sought ways to transplant tumours from sick mice to healthy mice. In this way they hoped to prolong their investigations beyond the lifetime of a single mouse. In most of these experiments the transplanted tumour did not grow in the healthy recipient mouse, but was rejected by mechanisms that were later shown to be due to an immune response. However, when inbred stocks of mice were used, successful transplantation and propagation of tumours became feasible. The observations so made suggested that one or more genetic factors control the acceptance and rejection of tumour grafts. An important question to arise from these studies was whether the observed effects were restricted to tumours or also pertained to normal tissue. The latter was shown to be true: transplanted healthy tissues were subject to the same type of immunological rejection as transplanted tumours. Further study of the phenomenon was made possible by the generation of highly inbred strains of mice which to all intents and purposes were genetically homogeneous. Tissue transplants between mice Of the same inbred strain were shown to be accepted, whereas transplants between mice of different strains were always rejected. Breeding expenments made
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