" it is appropriate to consider the response to
strict dieting of the very obese patient in group B, who
was withdrawn from the trial because of increasing
depression and physical incapacity due to her vast size.
When admitted to hospital she weighed 355 lb. (161 kg.),
and had no physical evidence of excessive fluid retention.
For 10 weeks she was given a 600-calorie diet; during
the first four to six weeks her activities were limited,
but thereafter her daily caloric expenditure was
increased by about 600 calories by walking. Over these
10 weeks a steady weight loss of 34 lb. (15.4 kg.)
occurred, which is almost exactly that expected from
the calculated mean daily deficit of 1,300 calories.
During this time she did not experience hunger and was
satisfied with her diet. This response is frequently
seen in such patients dieted in hospital; it emphasizes
that gross and persistent overeating is often due to
psychological disturbances or habit, and therefore may
well be refractory to the influence of the most effective
of anorectic agents. It also refutes any suggestion that
the obesity was due to irreversible abnormalities of
appetite or metabolism and could not, therefore, be
corrected by suitable reduction of food intake. "
'A double-blind trial of diethylpropion tenuate was carried out on 40 obese out-patients who had proved refractory to dietetic advice alone. The difference between their mean gain in weight when given dummy tablets and their mean loss of weight when taking diethylpropion was statistically highly significant at all times during the 12 weeks' administration of each preparation. The absolute weight loss was, however, disappointingly small and similar to that previously recorded with the amphetamines and phenmetrazine (preludin). No important side-effects occurred."
Diethylpropion (tenuate) tabs. 25 mg. q.i.d. .. 28 7/S dm( Shillings and dimes )
Phenmetrazine (preludin) tabs. 25 mg. t.i.d. 16 5
" Benzedrine" tabs. 5 mg. t.i.d. .. .. 5 10
" Dexedrine" tabs. 5 mg. ti.d. .. .. 5 1
Tab. amphetamine sulphate B.P. or B.N.F. 5 mg. t.i.d. 3 6
Tab. dexamphetamine sulphate B.P. or B.N.F. 5 mg. t.i.d. .2 7
https://www-ncbi-nlm-nih-gov.ezp-prod1.hul.harvard.edu/pmc/articles/PMC1953248/pdf/brmedj02888-0047.pdf
'A double-blind trial of diethylpropion tenuate was carried out on 40 obese out-patients who had proved refractory to dietetic advice alone. The difference between their mean gain in weight when given dummy tablets and their mean loss of weight when taking diethylpropion was statistically highly significant at all times during the 12 weeks' administration of each preparation. The absolute weight loss was, however, disappointingly small and similar to that previously recorded with the amphetamines and phenmetrazine (preludin). No important side-effects occurred."
Diethylpropion (tenuate) tabs. 25 mg. q.i.d. .. 28 7/S dm( Shillings and dimes )
Phenmetrazine (preludin) tabs. 25 mg. t.i.d. 16 5
" Benzedrine" tabs. 5 mg. t.i.d. .. .. 5 10
" Dexedrine" tabs. 5 mg. ti.d. .. .. 5 1
Tab. amphetamine sulphate B.P. or B.N.F. 5 mg. t.i.d. 3 6
Tab. dexamphetamine sulphate B.P. or B.N.F. 5 mg. t.i.d. .2 7
https://www-ncbi-nlm-nih-gov.ezp-prod1.hul.harvard.edu/pmc/articles/PMC1953248/pdf/brmedj02888-0047.pdf
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