HAART to ART
In 1981 the first three clinical descriptions of AIDS were published in the Morbidity and Mortality Weekly Report and later the New England Journal of Medicine. These reports described an epidemic of community-acquired Pneumocystis pneumonia, in most cases combined with oral thrush in previously healthy homosexual men, as well as chronic ulcerating perianal herpes infections (Gottlieb 1981a, Gottlieb 1981b, Masur 1981, Siegal 1981). A little later, in June 1982, a notice from the Centers for Disease Control and Prevention (CDC) on three PCP cases among hemophiliacs was issued (CDC 1982a). In the same year a case of cryptosporidiosis in a hemophiliac patient from 2 Pennsylvania (Eyster 1982) and an AIDS manifestation in an infant after a blood transfusion were reported (CDC 1982b). The occurrence of AIDS among hemophiliacs triggered a discussion of whether a viral infection could cause AIDS (Marx 1982). In particular, the similarity of populations at risk for AIDS and hepatitis B led to the hypothesis of a viral agent causing AIDS.
The HIV epidemic
In 1981 the first three clinical descriptions of AIDS were published in the Morbidity and Mortality Weekly Report and later the New England Journal of Medicine. These reports described an epidemic of community-acquired Pneumocystis pneumonia, in most cases combined with oral thrush in previously healthy homosexual men, as well as chronic ulcerating perianal herpes infections (Gottlieb 1981a, Gottlieb 1981b, Masur 1981, Siegal 1981). A little later, in June 1982, a notice from the Centers for Disease Control and Prevention (CDC) on three PCP cases among hemophiliacs was issued (CDC 1982a). In the same year a case of cryptosporidiosis in a hemophiliac patient from 2 Pennsylvania (Eyster 1982) and an AIDS manifestation in an infant after a blood transfusion were reported (CDC 1982b). The occurrence of AIDS among hemophiliacs triggered a discussion of whether a viral infection could cause AIDS (Marx 1982). In particular, the similarity of populations at risk for AIDS and hepatitis B led to the hypothesis of a viral agent causing AIDS.
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