Treatment with insulin is associated with worse outcome in patients with chronic heart failure and diabetes

CONCLUSIONS:

Whether insulin use is associated with poor outcomes in HF should be investigated further with controlled trials, as should the possibility that there may be safer alternative glucose-lowering treatments for patients with HF and type 2 diabetes mellitus.

© 2018 The Authors. European Journal of Heart Failure © 2018 European Society of Cardiology.

For example, diabetic patients with HF enrolled in CHARM who were treated with insulin had a greater risk of death than those who were not treated with insulin.

UCLA researchers for the first time showed that advanced heart failure patients with diabetes who are treated with insulin faced a mortality rate four times higher than heart failure patients with diabetes treated with oral medications.

Treatment with insulin is associated with a worse outcome in patients with chronic heart failure and diabetes. We investigated 15 control subjects and 3 groups of 15 patients each having type 2 diabetes (Group 1), CHF (Group 2), and diabetes and CHF (Group 3), to probe whether the addition of diabetes worsens lung diffusion in CHF and whether insulin counteracts this effect.77: 2097,

Dee. 24, '21 — the importance of blood sugar estimation in the diagnosis and treatment of diabetes, [F. M. Johns] New Orleans M.& S.J. 74: 244, Oct. '21

—regulation of sugar content of blood and its significance in pathogenesis of diabetes, [L. Polink] Med. This does not seem to be an unrealistic possibility if one considers the relationship between these variables and gas exchange, and the effect insulin has on pulmonary gas transfer in patients with diabetes in addition to HF.They believe, therefore, that the retinitis of diabetes is the retinitis of cardiovascular-renal disease, modified in appearance and in stage of occurrence, possibly by the metabolic disturbances associated with diabetes.

Many patients with diabetes and HF require insulin either as monotherapy or in combination with other glycemic agents in order to achieve adequate blood glucose control.

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