Acetylcysteine for nebulisation
Acetylcysteine injection is sometimes used in an unlicensed capacity as a mucolytic.
1 The adult dose is 3 –5 mL of acetylcysteine 20% injection, or 6 –10 mL of a 10% solution through a face mask or mouthpiece, nebulised three or four times daily with air (use of concentrated oxygen causes degradation). Acetylcysteine reacts with some materials, e.g. rubber, iron, copper and nickel, so ensure the nebuliser does not contain these. Nebulisation equipment should be cleaned immediately after use with hot water and left to air dry. Acetylcysteine may induce bronchospasm. As a precaution this can be avoided by either administration of a lower dose, diluting 1 mL of CPPC c01.tex V2 - 11/18/2015 1:44 P.M.
A acetylcysteine 20% injection in 5 mL sodium chloride 0.9% and nebulising 3 –4 mL, or preadministering a nebulised bronchodilator. Alternatively 1 –10 mL of a 20% solution or 2 –20 mL of a 10% solution may be given by nebulisation every 2 –6 hours.
Acetylcysteine injection is sometimes used in an unlicensed capacity as a mucolytic.
1 The adult dose is 3 –5 mL of acetylcysteine 20% injection, or 6 –10 mL of a 10% solution through a face mask or mouthpiece, nebulised three or four times daily with air (use of concentrated oxygen causes degradation). Acetylcysteine reacts with some materials, e.g. rubber, iron, copper and nickel, so ensure the nebuliser does not contain these. Nebulisation equipment should be cleaned immediately after use with hot water and left to air dry. Acetylcysteine may induce bronchospasm. As a precaution this can be avoided by either administration of a lower dose, diluting 1 mL of CPPC c01.tex V2 - 11/18/2015 1:44 P.M.
A acetylcysteine 20% injection in 5 mL sodium chloride 0.9% and nebulising 3 –4 mL, or preadministering a nebulised bronchodilator. Alternatively 1 –10 mL of a 20% solution or 2 –20 mL of a 10% solution may be given by nebulisation every 2 –6 hours.
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