Arthritis Treatments: NSAIDs
<![if !supportLists]>· <![endif]>
ARTHRITIS TREATMENTS: NSAIDS
| ||||
Generic
|
Brand
|
Strength
|
Form
|
Usual Dose
|
ACETIC ACIDS DERIVATIVES
| ||||
diclofenac
|
—
|
25mg, 50mg, 75mg
|
Adults: OA: 50mg 2−3 times daily or 75mg twice daily. RA: 50mg 3−4 times daily or 75mg twice daily. AS: 25mg 4 times daily, with an additional 25mg at bedtime if necessary.
Children: Not recommended. | |
50mg
|
tabs
|
Adults: OA: 50mg 2−3 times daily. RA: 50mg 3−4 times daily. AS: 25mg 4 times daily, may add 25mg at bedtime.
Children: Not recommended. | ||
100mg
|
ext‑rel tabs
|
Adults: OA: 100mg once daily. RA: 100mg once daily; rarely 100mg twice daily may be used.
Children: Not recommended. | ||
18mg, 35mg
|
caps
|
Adults: ≥18yrs: 35mg three times daily. Hepatic impairment: start at lowest dose; discontinue if efficacy is not achieved.
Children: <18yrs: not established. | ||
—
|
200mg, 300mg
|
caps
|
Adults: Initially 600mg−1g/day in 2−3 divided doses; usual max 1g/day in divided doses; may increase to 1.2g/day when needed.
Children: Not recommended. | |
400mg, 500mg
|
tabs
| |||
400mg, 500mg, 600mg
|
ext‑rel tabs
|
Adults: 400mg−1g once daily; max 1.2g/day.
Children: Not recommended. | ||
—
|
25mg, 50mg
|
caps
|
Adults: Acute gouty arthritis: 50mg 3 times daily until pain tolerable; then rapidly reduce dose to discontinue. Other conditions: initially 25mg 2−3 times daily. Increase if needed at weekly intervals by 25−50mg daily; max 200mg daily.
Children: <14yrs: usually not recommended. ≥2yrs: 1−2mg/kg/day in divided doses; max 3−4mg/kg/day (or 150−200mg/day whichever less). | |
50mg
|
supp
| |||
25mg/5mL
|
susp
| |||
—
|
500mg, 750mg
|
tabs
|
Adults: Initially 1g once daily; max 2g/day in 1 or 2 divided doses. Renal insufficiency (CrCl 30−49mL/min): initial max 750mg once daily, may increase to 1.5g/day; (CrCl <30mL/min): initial max 500mg once daily, may increase to 1g/day.
Children: Not recommended. | |
sulindac
|
200mg
|
scored tabs
|
Adults: 150mg twice daily; max 400mg/day. Acute painful shoulder or gouty arthritis: 200mg twice daily, usually for 7−14 days.
Children: Not recommended. | |
COX-2 INHIBITORS
| ||||
celecoxib
|
50mg, 100mg, 200mg, 400mg
|
caps
|
Adults: ≥18yrs: OA: 200mg once daily or 100mg twice daily. RA: 100−200mg twice daily. AS: 200mg in 1−2 divided doses; if no response after 6wks, 400mg once daily may be tried. <50kg: start at lowest recommended dose.
Children: <2yrs: not recommended.JRA: ≥2yrs (≥10kg to ≤25kg): 50mg twice daily; (>25kg): 100mg twice daily. | |
PROPIONIC ACIDS DERIVATIVES
| ||||
fenoprofen
|
200mg, 400mg
|
caps
|
Adults: 300mg−600mg 3 or 4 times daily. Max: 3.2g/day.
Children: <18yrs: not recommended. | |
flurbiprofen
|
50mg, 100mg
|
tabs
|
Adults: 200−300mg/day in 2−4 divided doses; max single dose 100mg. Reduce dosage for renal impairment.
Children: Not recommended. | |
—
|
400mg, 600mg, 800mg
|
tabs
|
Adults: RA, OA: 400−800mg 3−4 times daily; max 3.2g/day.
Children: JRA: 30−40mg/kg/day in 3−4 doses. May use 20mg/kg/day in 3−4 doses for milder disease. | |
—
|
200mg
|
ext‑rel caps*
|
Adults: 200mg daily.
Children: Not recommended. | |
naproxen
|
275mg
|
tabs
|
Adults: Arthritis, spondylitis: 275mg or 550mg twice daily. Tendinitis, bursitis: Initially 550mg, then 550mg every 12 hrs or 275mg every 6−8hrs; max 1.375g (first day), then max 1.1g/day.Acute gout: 825mg once then 275mg every 8hrs.
Children: <2yrs: not recommended. ≥2yrs:use susp form of naproxen. | |
550mg
|
tabs
| |||
375mg, 500mg, 750mg
|
controlled-rel tabs
|
Adults: RA, OA, or AS: 750mg−1g once daily; max 1.5g once daily. Acute tendonitis or bursitis: 1g once daily, or 1.5g once daily for a limited period; max 1g/day thereafter. Gout: 1−1.5g once daily for 1 day then 1g once daily until attack subsides.
Children: Not recommended. | ||
250mg, 375mg, 500mg
|
tabs
|
Adults: Arthritis, spondylitis: 250−500mg twice daily; max 1.5g/day (up to 6mos). Tendinitis, bursitis: 500mg once, then 500mg twice daily or 250mg every 6−8hrs; max (first day) 1.25g, then max 1g/day. Acute gout: 750mg once, then 250mg every 8hrs.
Children: <2yrs: not recommended. ≥2yrs:JRA: 5mg/kg twice daily. Other uses: Doses of 2.5−5mg/kg/dose, max 15mg/kg/day have been used. | ||
125mg/5mL
|
susp
| |||
375mg, 500mg
|
e-c tabs
|
Adults: 375−500mg twice daily.
Children: <2yrs: not recommended. ≥2yrs: use susp form. | ||
oxaprozin
|
600mg
|
scored caplets
|
Adults: RA (≥16yrs) or OA: 1.2 g once daily; max 1.8 g or 26 mg/kg daily, whichever is less, in divided doses. Low body weight, milder disease, or on dialysis: initially 600 mg once daily; max 1.2g daily.
Children: <6yrs: not recommended.JRA: 6−16yrs (22−31 kg): 600 mg once daily; (32−54 kg): 900 mg once daily; (≥55 kg): 1.2 g once daily. | |
PROPIONIC ACIDS DERIVATIVE + H2 BLOCKER
| ||||
ibuprofen + famotidine
|
800mg/26.6mg
|
tabs
|
Adults: RA, OA: 800mg/26.6mg three times daily. Use lowest effective dose for the shortest duration.
Children: Not recommended. | |
OXICAMS DERIVATIVES
| ||||
meloxicam
|
7.5mg, 15mg
|
tabs
|
Adults: ≥18yrs: 7.5mg once daily; max 15mg once daily. Hemodialysis: max 7.5mg/day.
Children: <2yrs: not recommended.JRA: ≥2yrs: 0.125mg/kg (max 7.5mg) once daily. | |
7.5mg/5mL
|
susp
| |||
piroxicam
|
10mg, 20mg
|
caps
|
Adults: 20mg daily; may give in 2 divided doses.
Children: Not recommended. | |
SALICYLATES
| ||||
aspirin
|
325mg
|
tabs, caplets, gelcaps
|
Adults: RA, arthritis and pleurisy of SLE: initially 3g daily in divided doses; target plasma salicylate level 150−300mcg/mL. OA: up to 3g/day in divided doses. Spondyloarthropathies: up to 4g/day in divided doses.
Children: JRA: initially 90−130mg/kg per day in divided doses; target plasma salicylate level 150−300mcg/mL. | |
81mg, 325mg, 500mg
|
e-c tabs
| |||
500mg
|
caplets, gelcaps
| |||
800mg
|
tabs†
| |||
—
|
500mg, 750mg, 1g
|
scored tabs
|
Adults: 3g daily at bedtime or in 2 divided doses.
Elderly: 750mg three times daily. Children: <12kg: not recommended. 12−37kg: 50mg/kg/day. >37kg: 2.25g/day. Both in 2 divided doses. | |
500mg/5mL
|
soln
| |||
—
|
250mg, 500mg
|
tabs
|
Adults: 250−500mg twice daily; max 1.5g/day.
Children: Not recommended. | |
—
|
500mg, 750mg
|
scored tabs
|
Adults: 3g daily in divided doses.
Children: Not recommended. | |
500mg
|
caps
| |||
NOTES
| ||||
Key: e‑c = enteric coated; ext‑rel = extended-release; supp = suppositories; susp = suspension; OA = Osteoarthritis; RA = Rheumatoid arthritis; AS = Ankylosing spondylitis; JRA = Juvenile rheumatoid arthritis
*Duexis is a fixed-combination tablet of ibuprofen and famotidine indicated for the relief of signs/symptoms of RA and OA and to decrease the risk of developing upper gastrointestinal ulcers (eg, gastric and/or duodenal ulcer), in patients who are taking ibuprofen for those indications.
†pH dependent release
Not an inclusive list of medications, official indications, and/or dosing details. Please see drug monograph
| ||||
No comments:
Post a Comment