$US1000 human genome to 100 INR human genome "the journey of Molecular Biology"

are digital archives of the African Pliocene, even of Devonian seas; walking repositories of wisdom out the Old days. You could spend a lifetime reading in this ancient library and die unsated by the wonder Of it. —RICHARD DAWKINS


The human genome is only one of the many complete genome sequences known. Taken together, genome sequences from organisms distributed widely among the branches of the tree of life give us a sense, only hinted at before, of the very great unity in detail of all life on Earth. This recognition has changed our perceptions, much as the first pictures of the Earth from space engendered a unified view of our planet.

 Intellectual struggles that occupied entire careers leave behind only terse conclusions, often without any appreciation of the experiments that established the facts, much less of the alternative hypothesis tested and rejected. The force of the scientists’ personalities and their foibles are forgotten. This is too bad: those who do not learn from the successes of history will find it harder to emulate them
Genomics is an interdisciplinary subject. The phenomena we want to explain are biological. But many fields contribute to the methods and the intellectual approaches that we bring to bear on the data. Physicists, mathematicians, computer scientists, engineers, chemists, clinical practitioners, and researchers, have all joined in the enterprise.
 the technical developments that have so greatly increased the data flow, the current state of our knowledge and understanding of the data, and applications to medicine and other fields.

DNA and protein sequences and structures, genomes and proteomes, databases and information retrieval, and bioinformatics and the World Wide Web.

The first nucleic acid sequencing, by groups led by F. Sanger and W. Gilbert, in the 1970s, was a breakthrough comparable to the discovery of the double helix of DNA. The challenges of sequencing stimulated spectacular improvements in technology. The first was the automation of the Sanger method. The original sequences of the human genome were accomplished by batteries of automated Sanger sequencers. Subsequently, a series of ‘new generations’ of novel approaches have brought the landmark goal, the $US1000 human genome, within reach. Where do all the data go?

DEFINITION Human Genome 3.158 Gb
LOCUS  HSGPOIOIOI DNA  DATE 04-25-03
 
ACCESSION Assembly 1.0
ORGANISM
"Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. Homo sapiens"

TITLE
/ source
/ chromosome
/ note
ORIGIN
The Sequence
1, 3150000000
"1-22, x, Y"
"Book of Life, Holy Grail, Human Blueprint"
61
121
181
241
301
361
421
agctcgctga
cctgcgctca
tggatttatc
tCttagagtg
acatattttg
gtcctttatg
aacttgttga
atgcaaacag
gacttcctgg
ggaggccttc
tgctcttcgc
tcccatctgt
caaattttgc
taagaatgat
agagctattg
ctataatttt
accccgcacc
accctctgct
gttgaagaag
Ctggagttga
atgctgaaac
ataaccaaaa
aaaatcattt
gcaaaaaagg
aggctgtggg
ctgggtaaag
tacaaaatgt
tcaaggaacc
ttctcaacca
ggagcctaca
gtgcttttca
aaaataactc
gtttctcaga
ttcattggaa
cattaatgct
tgtctccaca
gaagaaaggg
agaaagtacg
gcttgacaca
tcctgaacat
taactgggcc
cagaaagaaa
atgcagaaaa
aagtgtgacc
ccttcacagt
agatttagtc
ggtt tggagt
ctaaaagatg