genomics
Transcriptomics
proteomics
Diauxic Shift
The lac operon (lactose operon) is an operon required for the transport and metabolism of lactose in Escherichia coli and many other enteric bacteria. Although glucose is the preferred carbon source for most bacteria, the lac operon allows for the effective digestion of lactose when glucose is not available through the activity of beta-galactosidase.[1] Gene regulation of the lac operon was the first genetic regulatory mechanism to be understood clearly, so it has become a foremost example of prokaryotic gene regulation. It is often discussed in introductory molecular and cellular biology classes for this reason. This lactose metabolism system was used by Jacob and Monod to determine how a cell knows which enzyme to synthesize. Their work on the lac operon won them the Nobel Prize in Physiology in 1965
attempts to integrate our data and understanding, an area known as systems biology. Whereas classical biochemistry made great contributions to demonstrating the properties of proteins in isolation, our job now is to put things back together. Chapter 11, Systems Biology, presents a description of biological organization that is based on networks. Cells contain parallel sets of networks based on physical and logical interactions among molecules. Each network also has static and dynamic aspects. The ultimate, most profound, goal is a complete and integrated picture of all of life’s activity, from the molecule to the biosphere.
Palaeogenomics
English
Etymology
palaeo- + genomics
Noun
palaeogenomics
The study of ancient genomes, especially those of extinct organisms
In many ways, palaeogenomics began when the first ancient DNA sequence was reported. This first sequence was derived from a stuffed museum specimen of the quagga, an extinct mammal related to the zebra. Unspecified and unselected DNA was extracted from the quagga specimen, cloned into a bacterial library, and then sequenced. It took another 17 years and the development of PCR before two independent groups successfully sequenced the complete mitochondrial genomes from several extinct moa species. Only 4 years later, using the original approach of cloning nonspecific ancient DNA extract and shotgun sequencing, the first ancient nuclear DNA sequences were determined, this time from the extinct cave bear. Since these early successes, palaeogenomics has rapidly expanded, because of both technological development and increasing interest in ancient DNA research
Transcriptomics
proteomics
Diauxic Shift
The lac operon (lactose operon) is an operon required for the transport and metabolism of lactose in Escherichia coli and many other enteric bacteria. Although glucose is the preferred carbon source for most bacteria, the lac operon allows for the effective digestion of lactose when glucose is not available through the activity of beta-galactosidase.[1] Gene regulation of the lac operon was the first genetic regulatory mechanism to be understood clearly, so it has become a foremost example of prokaryotic gene regulation. It is often discussed in introductory molecular and cellular biology classes for this reason. This lactose metabolism system was used by Jacob and Monod to determine how a cell knows which enzyme to synthesize. Their work on the lac operon won them the Nobel Prize in Physiology in 1965
attempts to integrate our data and understanding, an area known as systems biology. Whereas classical biochemistry made great contributions to demonstrating the properties of proteins in isolation, our job now is to put things back together. Chapter 11, Systems Biology, presents a description of biological organization that is based on networks. Cells contain parallel sets of networks based on physical and logical interactions among molecules. Each network also has static and dynamic aspects. The ultimate, most profound, goal is a complete and integrated picture of all of life’s activity, from the molecule to the biosphere.
Palaeogenomics
English
Etymology
palaeo- + genomics
Noun
palaeogenomics
The study of ancient genomes, especially those of extinct organisms
In many ways, palaeogenomics began when the first ancient DNA sequence was reported. This first sequence was derived from a stuffed museum specimen of the quagga, an extinct mammal related to the zebra. Unspecified and unselected DNA was extracted from the quagga specimen, cloned into a bacterial library, and then sequenced. It took another 17 years and the development of PCR before two independent groups successfully sequenced the complete mitochondrial genomes from several extinct moa species. Only 4 years later, using the original approach of cloning nonspecific ancient DNA extract and shotgun sequencing, the first ancient nuclear DNA sequences were determined, this time from the extinct cave bear. Since these early successes, palaeogenomics has rapidly expanded, because of both technological development and increasing interest in ancient DNA research
No comments:
Post a Comment